CNKSR1

Connector enhancer of kinase suppressor of Ras 1

PDB rendering based on 1wwv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCNKSR1 ; CNK; CNK1
External IDsOMIM: 603272 MGI: 2670958 HomoloGene: 4604 GeneCards: CNKSR1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez10256194231
EnsemblENSG00000142675ENSMUSG00000028841
UniProtQ969H4A2A9K7
RefSeq (mRNA)NM_001297647NM_001081047
RefSeq (protein)NP_001284576NP_001074516
Location (UCSC)Chr 1:
26.5 – 26.52 Mb		Chr 4:
134.23 – 134.24 Mb
PubMed search

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.[1][2]

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.[2]

Interactions

CNKSR1 has been shown to interact with RhoD[3] and RASSF1.[4]

References

  1. ↑ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell 95 (3): 343–53. doi:10.1016/S0092-8674(00)81766-3. PMID 9814705.
  2. ↑ 2.0 2.1 "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".
  3. ↑ Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388. Vancouver style error (help)
  4. ↑ Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A et al. (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Therrien M, Wong AM, Kwan E, Rubin GM (1999). "Functional analysis of CNK in RAS signaling". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13259–63. doi:10.1073/pnas.96.23.13259. PMC 23935. PMID 10557308.
  • Hartsough MT, Morrison DK, Salerno M, Palmieri D, Ouatas T, Mair M et al. (2002). "Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway". J. Biol. Chem. 277 (35): 32389–99. doi:10.1074/jbc.M203115200. PMID 12105213.
  • Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature 427 (6971): 256–60. doi:10.1038/nature02237. PMID 14724641.
  • Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388. Vancouver style error (help)
  • Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A et al. (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.
  • Jaffe AB, Hall A, Schmidt A (2005). "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol. 15 (5): 405–12. doi:10.1016/j.cub.2004.12.082. PMID 15753034.
  • Ziogas A, Moelling K, Radziwill G (2005). "CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation". J. Biol. Chem. 280 (25): 24205–11. doi:10.1074/jbc.M413327200. PMID 15845549.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Fritz RD, Radziwill G (2006). "The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor". Biochem. Biophys. Res. Commun. 338 (4): 1906–12. doi:10.1016/j.bbrc.2005.10.168. PMID 16289034.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help)

External links