CLTC

Clathrin, heavy chain (Hc)

PDB rendering based on 1b89.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCLTC ; CHC; CHC17; CLH-17; CLTCL2; Hc
External IDsOMIM: 118955 MGI: 2388633 HomoloGene: 3572 GeneCards: CLTC Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez121367300
EnsemblENSG00000141367ENSMUSG00000047126
UniProtQ00610Q68FD5
RefSeq (mRNA)NM_001288653NM_001003908
RefSeq (protein)NP_001275582NP_001003908
Location (UCSC)Chr 17:
57.7 – 57.77 Mb		Chr 11:
86.69 – 86.76 Mb
PubMed search

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.[1][2]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[3]

Interactions

CLTC has been shown to interact with PICALM[4] and HGS.[5]

See also

References

  1. ↑ Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375.
  2. ↑ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  3. ↑ "Entrez Gene: CLTC clathrin, heavy chain (Hc)".
  4. ↑ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell (UNITED STATES) 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.
  5. ↑ Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. (England) 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964.

Further reading

  • Murphy JE, Keen JH (1992). "Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia.". J. Biol. Chem. 267 (15): 10850–5. PMID 1587861.
  • Corvera S (1990). "Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes.". J. Biol. Chem. 265 (5): 2413–6. PMID 2154445.
  • Scarmato P, Kirchhausen T (1990). "Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3.". J. Biol. Chem. 265 (7): 3661–8. PMID 2406259.
  • Hanspal M, Luna E, Branton D (1984). "The association of clathrin fragments with coated vesicle membranes.". J. Biol. Chem. 259 (17): 11075–82. PMID 6147350.
  • Nomura N, Miyajima N, Sazuka T et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  • Fausser JL, Ungewickell E, Ruch JV, Lesot H (1994). "Interaction of vinculin with the clathrin heavy chain.". J. Biochem. 114 (4): 498–503. PMID 8276759.
  • Kedra D, Peyrard M, Fransson I et al. (1997). "Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.". Hum. Mol. Genet. 5 (5): 625–31. doi:10.1093/hmg/5.5.625. PMID 8733129.
  • Goodman OB, Krupnick JG, Gurevich VV et al. (1997). "Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain.". J. Biol. Chem. 272 (23): 15017–22. doi:10.1074/jbc.272.23.15017. PMID 9169477.
  • Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform.". J. Biol. Chem. 272 (26): 16700–6. doi:10.1074/jbc.272.26.16700. PMID 9195986.
  • McMahon HT, Wigge P, Smith C (1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin.". FEBS Lett. 413 (2): 319–22. doi:10.1016/S0014-5793(97)00928-9. PMID 9280305.
  • Foti M, Mangasarian A, Piguet V et al. (1998). "Nef-mediated clathrin-coated pit formation.". J. Cell Biol. 139 (1): 37–47. doi:10.1083/jcb.139.1.37. PMC 2139808. PMID 9314527.
  • Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin.". Science 280 (5362): 431–4. doi:10.1126/science.280.5362.431. PMID 9545220.
  • Ramjaun AR, McPherson PS (1998). "Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.". J. Neurochem. 70 (6): 2369–76. doi:10.1046/j.1471-4159.1998.70062369.x. PMID 9603201.
  • ter Haar E, Musacchio A, Harrison SC, Kirchhausen T (1998). "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.". Cell 95 (4): 563–73. doi:10.1016/S0092-8674(00)81623-2. PMID 9827808.
  • Laporte SA, Oakley RH, Zhang J et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. doi:10.1073/pnas.96.7.3712. PMC 22359. PMID 10097102.
  • Turner CE, Brown MC, Perrotta JA et al. (1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling.". J. Cell Biol. 145 (4): 851–63. doi:10.1083/jcb.145.4.851. PMC 2133183. PMID 10330411.
  • Hussain NK, Yamabhai M, Ramjaun AR et al. (1999). "Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells.". J. Biol. Chem. 274 (22): 15671–7. doi:10.1074/jbc.274.22.15671. PMID 10336464.
  • Ybe JA, Brodsky FM, Hofmann K et al. (1999). "Clathrin self-assembly is mediated by a tandemly repeated superhelix.". Nature 399 (6734): 371–5. doi:10.1038/20708. PMID 10360576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.