CLK1

"CLK-1" redirects here. For the ship designated CLK-1, see USS Norfolk (DL-1).
CDC-like kinase 1

PDB rendering based on 1z57.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCLK1 ; CLK; CLK/STY; STY
External IDsOMIM: 601951 HomoloGene: 101535 IUPHAR: 1990 ChEMBL: 4224 GeneCards: CLK1 Gene
EC number2.7.12.1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez119512747
EnsemblENSG00000013441ENSMUSG00000026034
UniProtP49759P22518
RefSeq (mRNA)NM_001024646NM_001042634
RefSeq (protein)NP_001155879NP_001036099
Location (UCSC)Chr 2:
201.72 – 201.73 Mb
Chr 1:
58.41 – 58.42 Mb
PubMed search

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.[1][2]

Function

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.[2]

Interactions

CLK1 has been shown to interact with ASF/SF2.[3][4]

References

  1. Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501.
  2. 2.0 2.1 "Entrez Gene: CLK1 CDC-like kinase 1".
  3. Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T et al. (Oct 1996). "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. Chem. 271 (40): 24569–75. doi:10.1074/jbc.271.40.24569. PMID 8798720. Vancouver style error (help)
  4. Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T et al. (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863.

Further reading