CIR (gene)

Corepressor interacting with RBPJ, 1

Identifiers

CIR1 ; CIR

External IDs

OMIM: 605228 MGI: 1914185 HomoloGene: 3589 GeneCards: CIR1 Gene

Gene ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • transcription corepressor activity • protein binding
Cellular component	• histone deacetylase complex • nucleus • cytoplasm • microtubule organizing center • nuclear speck
Biological process	• regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • mRNA processing • RNA splicing • negative regulation of transcription, DNA-templated
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000138433

ENSMUSG00000041777

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
175.21 – 175.26 Mb

Chr 2:
73.28 – 73.31 Mb

PubMed search

Corepressor interacting with RBPJ 1 is a protein that in humans is encoded by the CIR1 gene.^[1]^[2]^[3]^[4]

Interactions

CIR (gene) has been shown to interact with SNW1.^[5]

References

↑ Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (January 2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Exp Cell Res 303 (2): 375–87. doi:10.1016/j.yexcr.2004.10.012. PMID 15652350.
↑ Zhang J, Chen H, Weinmaster G, Hayward SD (March 2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC". J Virol 75 (6): 2946–56. doi:10.1128/JVI.75.6.2946-2956.2001. PMC 115921. PMID 11222720.
↑ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (March 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proc Natl Acad Sci U S A 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
↑ "Entrez Gene: CIR CBF1 interacting corepressor".
↑ Zhou, S; Fujimuro M; Hsieh J J; Chen L; Hayward S D (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". J. Virol. (UNITED STATES) 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. ISSN 0022-538X. PMC 111672. PMID 10644367.

Further reading

DuBridge RB, Tang P, Hsia HC et al. (1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.". Mol. Cell. Biol. 7 (1): 379–87. PMC 365079. PMID 3031469.
Zhou S, Fujimuro M, Hsieh JJ et al. (2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters.". J. Virol. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
Krithivas A, Young DB, Liao G et al. (2000). "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells.". J. Virol. 74 (20): 9637–45. doi:10.1128/JVI.74.20.9637-9645.2000. PMC 112396. PMID 11000236.
Zhou S, Hayward SD (2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex.". Mol. Cell. Biol. 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
Suzuki H, Fukunishi Y, Kagawa I et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.