CIRBP

Cold inducible RNA binding protein

PDB rendering based on 1x5s.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCIRBP ; CIRP
External IDsOMIM: 602649 MGI: 893588 HomoloGene: 980 GeneCards: CIRBP Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez115312696
EnsemblENSG00000099622ENSMUSG00000045193
UniProtQ14011P60824
RefSeq (mRNA)NM_001280NM_007705
RefSeq (protein)NP_001271NP_031731
Location (UCSC)Chr 19:
1.26 – 1.27 Mb
Chr 10:
80.17 – 80.17 Mb
PubMed search

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene.[1][2][3] The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia.

References

  1. Nishiyama H, Higashitsuji H, Yokoi H, Itoh K, Danno S, Matsuda T, Fujita J (Feb 1998). "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene". Gene 204 (1–2): 115–20. doi:10.1016/S0378-1119(97)00530-1. PMID 9434172.
  2. Nishiyama H, Itoh K, Kaneko Y, Kishishita M, Yoshida O, Fujita J (Jun 1997). "A Glycine-rich RNA-binding Protein Mediating Cold-inducible Suppression of Mammalian Cell Growth". J Cell Biol 137 (4): 899–908. doi:10.1083/jcb.137.4.899. PMC 2139845. PMID 9151692.
  3. "Entrez Gene: CIRBP cold inducible RNA binding protein".

Further reading