CIDEA
Cell death activator CIDE-A is a protein that in humans is encoded by the CIDEA gene.[1][2][3] Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. [4]
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.[3]
References
- ↑ Inohara N, Koseki T, Chen S, Wu X, Nunez G (Jun 1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor". EMBO J 17 (9): 2526–33. doi:10.1093/emboj/17.9.2526. PMC 1170594. PMID 9564035.
- ↑ Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP (Jun 2008). "Cidea is associated with lipid droplets and insulin sensitivity in humans". Proc Natl Acad Sci U S A 105 (22): 7833–8. doi:10.1073/pnas.0802063105. PMC 2409392. PMID 18509062.
- ↑ 3.0 3.1 "Entrez Gene: CIDEA cell death-inducing DFFA-like effector a".
- ↑ Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids
Further reading
- Zhang L, Miyaki K, Nakayama T, Muramatsu M (2008). "Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men". Metab. Clin. Exp. 57 (4): 502–5. doi:10.1016/j.metabol.2007.11.011. PMID 18328351.
- Li D, Da L, Tang H et al. (2008). "CpG methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing DFF45-like effector A gene through the regulation of Sp1/Sp3 binding". Nucleic Acids Res. 36 (1): 330–41. doi:10.1093/nar/gkm1028. PMC 2248752. PMID 18033804.
- Gummesson A, Jernås M, Svensson PA et al. (2008). "Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studies". J. Clin. Endocrinol. Metab. 92 (12): 4759–65. doi:10.1210/jc.2007-1136. PMID 17895319.
- Iwahana H, Yakymovych I, Dubrovska A et al. (2007). "Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis". Proteomics 6 (23): 6168–80. doi:10.1002/pmic.200600384. PMID 17080483.
- Dahlman I, Kaaman M, Jiao H et al. (2005). "The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects". Diabetes 54 (10): 3032–4. doi:10.2337/diabetes.54.10.3032. PMID 16186410.
- Nordström EA, Rydén M, Backlund EC et al. (2005). "A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity". Diabetes 54 (6): 1726–34. doi:10.2337/diabetes.54.6.1726. PMID 15919794.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Zhou Z, Yon Toh S, Chen Z et al. (2003). "Cidea-deficient mice have lean phenotype and are resistant to obesity". Nat. Genet. 35 (1): 49–56. doi:10.1038/ng1225. PMID 12910269.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chen Z, Guo K, Toh SY et al. (2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis". J. Biol. Chem. 275 (30): 22619–22. doi:10.1074/jbc.C000207200. PMID 10837461.