CETN3

Centrin, EF-hand protein, 3

Identifiers

CETN3 ; CDC31; CEN3

External IDs

OMIM: 602907 MGI: 1097706 HomoloGene: 74521 GeneCards: CETN3 Gene

Gene ontology
Molecular function	• calcium ion binding • microtubule binding • G-protein beta/gamma-subunit complex binding
Cellular component	• cytoplasm • centrosome • centriole • photoreceptor connecting cilium • intermediate filament cytoskeleton
Biological process	• mitotic nuclear division • centrosome cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000153140

ENSMUSG00000021537

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
89.69 – 89.71 Mb

Chr 13:
81.78 – 81.8 Mb

PubMed search

Centrin-3 is a protein that in humans is encoded by the CETN3 gene.^[1]^[2] It belongs to the centrin family of proteins.

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.^[2]

References

↑ Middendorp S, Paoletti A, Schiebel E, Bornens M (Sep 1997). "Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene". Proc Natl Acad Sci U S A 94 (17): 9141–6. doi:10.1073/pnas.94.17.9141. PMC 23077. PMID 9256449.
↑ 2.0 2.1 "Entrez Gene: CETN3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast)".

Further reading

Salisbury JL (2004). "Centrosomes: Sfi1p and centrin unravel a structural riddle". Curr. Biol. 14 (1): R27–9. doi:10.1016/j.cub.2003.12.019. PMID 14711432.
Wiech H, Geier BM, Paschke T et al. (1996). "Characterization of green alga, yeast, and human centrins. Specific subdomain features determine functional diversity". J. Biol. Chem. 271 (37): 22453–61. doi:10.1074/jbc.271.37.22453. PMID 8798410.
Paoletti A, Moudjou M, Paintrand M et al. (1997). "Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles". J. Cell. Sci. 109 (13): 3089–102. PMID 9004043.
LeDizet M, Beck JC, Finkbeiner WE (1999). "Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells". Am. J. Physiol. 275 (6 Pt 1): L1145–56. PMID 9843852.
Laoukili J, Perret E, Middendorp S et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro". J. Cell. Sci. 113 (8): 1355–64. PMID 10725219.
Lutz W, Lingle WL, McCormick D et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Schiebel E, Bornens M (2004). "In search of a function for centrins". Trends Cell Biol. 5 (5): 197–201. doi:10.1016/S0962-8924(00)88999-0. PMID 14731449.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cox JA, Tirone F, Durussel I et al. (2005). "Calcium and magnesium binding to human centrin 3 and interaction with target peptides". Biochemistry 44 (3): 840–50. doi:10.1021/bi048294e. PMID 15654740.
Poole E, Strappe P, Mok HP et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET". Traffic 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678.
Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.