CETN1

Centrin, EF-hand protein, 1

PDB rendering based on 1m39.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCETN1 ; CEN1; CETN
External IDsOMIM: 603187 MGI: 1347086 HomoloGene: 105668 GeneCards: CETN1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez106826369
EnsemblENSG00000177143ENSMUSG00000050996
UniProtQ12798P41209
RefSeq (mRNA)NM_004066NM_007593
RefSeq (protein)NP_004057NP_031619
Location (UCSC)Chr 18:
0.58 – 0.58 Mb
Chr 18:
9.62 – 9.62 Mb
PubMed search

Centrin-1 is a protein that in humans is encoded by the CETN1 gene.[1][2] It belongs to the centrin family of proteins.

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[2]

References

  1. Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. PMID 8175926.
  2. 2.0 2.1 "Entrez Gene: CETN1 centrin, EF-hand protein, 1".

Further reading