CEP55

Centrosomal protein 55kDa

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3E1R

Identifiers

Symbols

CEP55 ; C10orf3; CT111; URCC6

External IDs

OMIM: 610000 MGI: 1921357 HomoloGene: 10019 GeneCards: CEP55 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• centrosome • centriole • membrane • midbody • cleavage furrow • intercellular bridge
Biological process	• mitotic cytokinesis • mitotic nuclear division • establishment of protein localization
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
95.26 – 95.29 Mb

Chr 19:
38.06 – 38.07 Mb

PubMed search

Centrosomal protein of 55 kDa is a protein that in humans is encoded by the CEP55 gene.^[1]^[2]

CEP55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.^[3]

References

↑ Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis". Dev Cell 9 (4): 477–88. doi:10.1016/j.devcel.2005.09.003. PMID 16198290.
↑ "Entrez Gene: CEP55 centrosomal protein 55kDa".
↑ van der Horst A, Simmons J, Khanna KK (November 2009). "Cep55 stabilization is required for normal execution of cytokinesis". Cell Cycle 8 (22): 3742–9. doi:10.4161/cc.8.22.10047. PMID 19855176.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K (2006). "The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody". Genomics 87 (2): 243–53. doi:10.1016/j.ygeno.2005.11.006. PMID 16406728.
Zhao WM, Seki A, Fang G (2006). "Cep55, a Microtubule-bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis". Mol. Biol. Cell 17 (9): 3881–96. doi:10.1091/mbc.E06-01-0015. PMC 1593165. PMID 16790497.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chen CH, Lu PJ, Chen YC et al. (2007). "FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway". Oncogene 26 (29): 4272–83. doi:10.1038/sj.onc.1210207. PMID 17237822.
Carlton JG, Martin-Serrano J (2007). "Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery". Science 316 (5833): 1908–12. doi:10.1126/science.1143422. PMID 17556548.
Morita E, Sandrin V, Chung HY et al. (2007). "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis". EMBO J. 26 (19): 4215–27. doi:10.1038/sj.emboj.7601850. PMC 2230844. PMID 17853893.

The centrosome and its components

Centrioles

SASS6
CENPJ
CNTROB
CEP104
Centrins (CETN1, CETN2 and CETN3)
SFI1

Pericentriolar material

other proteins

Index of cells

Description	Structure nucleus chromosome genetics Organelles peroxisome cytoskeleton centrosome epithelia cilia mitochondria Membranes proteins cell adhesions Membrane transport ion channels vesicular transport solute carrier ABC transporters ATPase oxidoreduction-driven

Disease	Structural peroxisome cytoskeleton cilia mitochondria nucleus scleroprotein Membrane channelopathy solute carrier ATPase ABC transporters other extracellular ligands cell surface receptors intracellular signalling Vesicular transport Pore-forming toxins

CEP55

References

Further reading