CEP170
| Centrosomal protein 170kDa | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CEP170 ; FAM68A; KAB; KIAA0470 | ||||||||||||
| External IDs | OMIM: 613023 MGI: 1918348 HomoloGene: 22844 GeneCards: CEP170 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9859 | 545389 | |||||||||||
| Ensembl | ENSG00000143702 | ENSMUSG00000057335 | |||||||||||
| UniProt | Q5SW79 | Q6A065 | |||||||||||
| RefSeq (mRNA) | NM_001042404 | NM_001024722 | |||||||||||
| RefSeq (protein) | NP_001035863 | NP_001093107 | |||||||||||
| Location (UCSC) | Chr 1: 243.29 – 243.42 Mb | Chr 1: 176.73 – 176.81 Mb | |||||||||||
| PubMed search | |||||||||||||
Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[1][2]
Function
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1 ) and polo-like kinase 1 ( PLK1 ), and functions in maintaining Microtubule organization, cell morphology and cilium stability.[1]
The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[1]
References
- ↑ 1.0 1.1 1.2 "Entrez Gene: CEP170 centrosomal protein 170kDa".
- ↑ Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
Further reading
- Andersen JS, Wilkinson CJ, Mayor T et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling.". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
- Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Guarguaglini G, Duncan PI, Stierhof YD et al. (2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.". Mol. Biol. Cell 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.
- Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Lamla S (2009). "Functional characterisation of the centrosomal protein Cep170.". Dissertation, LMU Muenchen: Fakultät für Biologie. URN nbn:de:bvb:19-97838.
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