CENTG1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

PDB rendering based on 2bmj.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2BMJ, 2IWR, 2RLO

Identifiers

Symbols

AGAP2 ; CENTG1; GGAP2; PIKE

External IDs

OMIM: 605476 HomoloGene: 86815 GeneCards: AGAP2 Gene

Gene ontology
Molecular function	• protein binding • GTP binding • ARF GTPase activator activity • zinc ion binding
Cellular component	• nucleus • nucleolus • mitochondrion • membrane
Biological process	• small GTPase mediated signal transduction • axon guidance • protein transport • regulation of ARF GTPase activity • negative regulation of protein catabolic process • negative regulation of neuron apoptotic process • positive regulation of GTPase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
58.12 – 58.12 Mb

Chr 10:
127.08 – 127.09 Mb

PubMed search

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene.^[1]

Interactions

CENTG1 has been shown to interact with:

References

↑ "Entrez Gene: CENTG1 centaurin, gamma 1".
↑ 2.0 2.1 Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ et al. (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
↑ Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA et al. (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.

Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.". Genomics 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ et al. (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.". Cell 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ et al. (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.". Nature 415 (6871): 541–4. doi:10.1038/415541a. PMID 11823862.
Nie Z, Stanley KT, Stauffer S, Jacques KM, Hirsch DS, Takei J et al. (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.". J. Biol. Chem. 277 (50): 48965–75. doi:10.1074/jbc.M202969200. PMID 12388557.
Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.". Mol. Cell. Biol. 23 (7): 2476–88. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.
Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.". J. Biol. Chem. 279 (16): 16441–51. doi:10.1074/jbc.M312175200. PMID 14761976.
Ahn JY, Hu Y, Kroll TG, Allard P, Ye K (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. doi:10.1073/pnas.0400921101. PMC 406454. PMID 15118108.
Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3.". J. Cell. Sci. 118 (Pt 15): 3555–66. doi:10.1242/jcs.02486. PMID 16079295.
Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.". Neuropathol. Appl. Neurobiol. 31 (5): 486–90. doi:10.1111/j.1365-2990.2005.00660.x. PMID 16150119.
Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. doi:10.1073/pnas.0507365102. PMC 1283830. PMID 16263930.
Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.". Cell Death Differ. 14 (2): 368–77. doi:10.1038/sj.cdd.4402011. PMID 16841086.
Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase.". Biochem. J. 401 (3): 679–88. doi:10.1042/BJ20060555. PMC 1770848. PMID 17037982.
Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.". J. Virol. 81 (5): 2340–8. doi:10.1128/JVI.01310-06. PMC 1865929. PMID 17151107.
Liu X, Hu Y, Hao C, Rempel SA, Ye K (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.". Oncogene 26 (34): 4918–27. doi:10.1038/sj.onc.1210290. PMID 17297440.
Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2.". Traffic 8 (6): 661–72. doi:10.1111/j.1600-0854.2007.00561.x. PMID 17461797.

PDB gallery

2bmj: GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)

2iwr: GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)

CENTG1

Interactions

References

Further reading