CED-12

CED-12 is the C. elegans ortholog of the ELMO family of mammalian adaptor proteins. It interacts with CED-5 (the C. elegans ortholog of mammalian Dock180) to form a bipartite guanine nucleotide exchange factor which promotes cell migration and phagocytosis of apoptotic cells.[1]

References

  1. ↑ Gumienny TL, Brugnera E, Tosello-Trampont AC et al. (June 2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration". Cell 107 (1): 27–41. doi:10.1016/S0092-8674(01)00520-7. PMID 11595183.