CDKL2

Cyclin-dependent kinase-like 2 (CDC2-related kinase)

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4AAA, 4BBM

Identifiers

CDKL2 ; KKIAMRE; P56

External IDs

OMIM: 603442 MGI: 1858227 HomoloGene: 55793 IUPHAR: 1983 ChEMBL: 5728 GeneCards: CDKL2 Gene

Gene ontology
Molecular function	• protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • ATP binding
Cellular component	• nucleus • cytoplasm
Biological process	• protein phosphorylation • signal transduction • sex differentiation • regulation of cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000138769

ENSMUSG00000029403

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
76.5 – 76.56 Mb

Chr 5:
92.01 – 92.04 Mb

PubMed search

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.^[1]^[2]

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.^[2]

References

↑ Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene 13 (12): 2563–74. PMID 9000130.
↑ 2.0 2.1 "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

Further reading

Marracci GH; Marquardt WE; Strehlow A et al. (2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochem. Biophys. Res. Commun. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
Sarkar SN; Peters KL; Elco CP et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nat. Struct. Mol. Biol. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID 15502848.
Tao J; Van Esch H; Hagedorn-Greiwe M et al. (2005). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation". Am. J. Hum. Genet. 75 (6): 1149–1154. doi:10.1086/426460. PMC 1182152. PMID 15499549.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC (1995). "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors". J. Biol. Chem. 270 (16): 9115–9120. doi:10.1074/jbc.270.16.9115. PMID 7721825.