CDCA8
| Cell division cycle associated 8 | |||||||||||||
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 Rendering based on PDB 2KDD. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CDCA8 ; BOR; BOREALIN; DasraB; MESRGP | ||||||||||||
| External IDs | OMIM: 609977 MGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55143 | 52276 | |||||||||||
| Ensembl | ENSG00000134690 | ENSMUSG00000028873 | |||||||||||
| UniProt | Q53HL2 | Q8BHX3 | |||||||||||
| RefSeq (mRNA) | NM_001256875 | NM_026560 | |||||||||||
| RefSeq (protein) | NP_001243804 | NP_080836 | |||||||||||
| Location (UCSC) | Chr 1: 38.16 – 38.18 Mb | Chr 4: 124.92 – 124.94 Mb | |||||||||||
| PubMed search | |||||||||||||
Borealin is a protein that in humans is encoded by the CDCA8 gene.[1][2][3]
Function
CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle (Gassmann et al., 2004).[supplied by OMIM][3]
Interactions
CDCA8 has been shown to interact with INCENP,[4] Survivin[2][4] and Aurora B kinase.[2][4]
References
- ↑ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
- ↑ 2.0 2.1 2.2 Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
- ↑ 3.0 3.1 "Entrez Gene: CDCA8 cell division cycle associated 8".
- ↑ 4.0 4.1 4.2 Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R et al. (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
Further reading
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R et al. (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
- Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH (Jan 2005). "Proteome analysis of the human mitotic spindle". Molecular & Cellular Proteomics : MCP 4 (1): 35–43. doi:10.1074/mcp.M400158-MCP200. PMID 15561729. Vancouver style error (help)
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI et al. (Jan 2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Vader G, Kauw JJ, Medema RH, Lens SM (Jan 2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Reports 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMC 1369225. PMID 16239925.
- Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P et al. (Jan 2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". The Journal of Biological Chemistry 281 (2): 1286–95. doi:10.1074/jbc.M508773200. PMID 16291752.
- Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH et al. (Apr 2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research 312 (7): 962–73. doi:10.1016/j.yexcr.2005.12.015. PMID 16427043.
- Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH (Apr 2006). "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres". Molecular Biology of the Cell 17 (4): 1897–909. doi:10.1091/mbc.E05-08-0727. PMC 1415303. PMID 16436504.
- Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA et al. (Aug 2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene 25 (35): 4867–79. doi:10.1038/sj.onc.1209499. PMID 16547492.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. Vancouver style error (help)
- Klein UR, Nigg EA, Gruneberg U (Jun 2006). "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP". Molecular Biology of the Cell 17 (6): 2547–58. doi:10.1091/mbc.E05-12-1133. PMC 1474794. PMID 16571674.
- Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of borealin". BMC Cell Biology 8: 5. doi:10.1186/1471-2121-8-5. PMC 1794407. PMID 17241471.
- Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M et al. (May 2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis". Cancer Research 67 (9): 4113–22. doi:10.1158/0008-5472.CAN-06-4705. PMID 17483322.