CDC23

Cell division cycle 23

Identifiers

CDC23 ; ANAPC8; APC8; CUT23

External IDs

OMIM: 603462 MGI: 1098815 HomoloGene: 3426 GeneCards: CDC23 Gene

Gene ontology
Molecular function	• ubiquitin-protein transferase activity
Cellular component	• intracellular • nucleoplasm • anaphase-promoting complex • cytosol
Biological process	• mitotic G1 phase • mitotic cell cycle • ubiquitin-dependent protein catabolic process • cell cycle • mitotic nuclear division • mitotic metaphase plate congression • metaphase/anaphase transition of mitotic cell cycle • mitotic spindle assembly checkpoint • regulation of exit from mitosis • regulation of mitotic metaphase/anaphase transition • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein K11-linked ubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
137.52 – 137.55 Mb

Chr 18:
34.63 – 34.65 Mb

PubMed search

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.^[1]

Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.^[1]

Interactions

CDC23 has been shown to interact with CDC27.^[2]^[3]

References

↑ 1.0 1.1 "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)".
↑ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology : CB 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. CS1 maint: Date and year (link)
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. CS1 maint: Date and year (link)
Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (Feb 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science (New York, N.Y.) 279 (5354): 1219–22. doi:10.1126/science.279.5354.1219. PMID 9469815. CS1 maint: Date and year (link)
Zhao N, Lai F, Fernald AA, Eisenbart JD, Espinosa R, Wang PW et al. (Oct 1998). "Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics 53 (2): 184–90. doi:10.1006/geno.1998.5473. PMID 9790767. CS1 maint: Date and year (link)
Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K et al. (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877. CS1 maint: Date and year (link)
Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (Sep 1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proceedings of the National Academy of Sciences of the United States of America 96 (20): 11317–22. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174. CS1 maint: Date and year (link)
Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056. CS1 maint: Date and year (link)
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. Check date values in: |year= / |date= mismatch (help)
Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893. Check date values in: |year= / |date= mismatch (help)
Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T et al. (Mar 2003). "Alterations of anaphase-promoting complex genes in human colon cancer cells". Oncogene 22 (10): 1486–90. doi:10.1038/sj.onc.1206224. PMID 12629511. CS1 maint: Date and year (link)
Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology : CB 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. Check date values in: |year= / |date= mismatch (help)
Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J et al. (Dec 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031. Check date values in: |year= / |date= mismatch (help)
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J et al. (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. Vancouver style error (help) CS1 maint: Date and year (link)
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics : MCP 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. Check date values in: |year= / |date= mismatch (help); Vancouver style error (help)
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. CS1 maint: Date and year (link)
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. Vancouver style error (help) CS1 maint: Date and year (link)
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help) CS1 maint: Date and year (link)
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. CS1 maint: Date and year (link)

CDC23

Function

Interactions

References

Further reading