CD7
| CD7 molecule | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CD7 ; GP40; LEU-9; TP41; Tp40 | ||||||||||||
| External IDs | OMIM: 186820 MGI: 88344 HomoloGene: 4471 GeneCards: CD7 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 924 | 12516 | |||||||||||
| Ensembl | ENSG00000173762 | ENSMUSG00000025163 | |||||||||||
| UniProt | P09564 | P50283 | |||||||||||
| RefSeq (mRNA) | NM_006137 | NM_009854 | |||||||||||
| RefSeq (protein) | NP_006128 | NP_033984 | |||||||||||
| Location (UCSC) | Chr 17: 80.27 – 80.28 Mb | Chr 11: 121.04 – 121.04 Mb | |||||||||||
| PubMed search | |||||||||||||
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[1]
Function
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]
See also
Interactions
CD7 has been shown to interact with PIK3R1.[2][3]
Clinical significance
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[4] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[5]
References
- ↑ 1.0 1.1 "Entrez Gene: CD7 CD7 molecule".
- ↑ Lee DM, Patel DD, Pendergast AM, Haynes BF (Aug 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
- ↑ Subrahmanyam G, Rudd CE, Schneider H (Jan 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831.
- ↑ Yasuko H, Hideto T, Mariko I, Namiko O, Asaka K, Keiichi M et al. (2013). "CD7 Expression On Blasts Of Myelodysplastic Syndromes Is Associated With Apoptosis Resistance With Decreased Expression Of The Proapoptotic Protein Bad and An Independent Unfavorable Prognostic Factor Together With The Revised IPSS Score In Patients". Blood 122 (21): 2799.
- ↑ Stevens SR, Baron ED, Masten S, Cooper KD (2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Arch Dermatol 138 (10): 1347–50. doi:10.1001/archderm.138.10.1347. PMID 12374541.
Further reading
- Stillwell R, Bierer BE (2002). "T cell signal transduction and the role of CD7 in costimulation.". Immunol. Res. 24 (1): 31–52. doi:10.1385/IR:24:1:31. PMID 11485208.
- Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM (1990). "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization.". Immunogenetics 31 (5-6): 412–3. doi:10.1007/BF02115022. PMID 1695199.
- Schanberg LE, Fleenor DE, Kurtzberg J, Haynes BF, Kaufman RE (1991). "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 603–7. doi:10.1073/pnas.88.2.603. PMC 50860. PMID 1703303.
- Yoshikawa K, Seto M, Ueda R, Obata Y, Notake K, Yokochi T et al. (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7.". Immunogenetics 33 (5-6): 352–60. doi:10.1007/BF00216694. PMID 1711009.
- Ware RE, Scearce RM, Dietz MA, Starmer CF, Palker TJ, Haynes BF (1990). "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.". J. Immunol. 143 (11): 3632–40. PMID 2479685.
- Osada S, Utsumi KR, Ueda R, Akao Y, Tsuge I, Nishida K et al. (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17.". Cytogenet. Cell Genet. 47 (1-2): 8–10. doi:10.1159/000132494. PMID 3258561.
- Aruffo A, Seed B (1988). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.". EMBO J. 6 (11): 3313–6. PMC 553785. PMID 3501369.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Lee DM, Schanberg LE, Fleenor DE, Seldin MF, Haynes BF, Kaufman RE (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters.". Immunogenetics 44 (2): 108–14. doi:10.1007/s002510050097. PMID 8662072.
- Bevec T, Stoka V, Pungercic G, Dolenc I, Turk V (1996). "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.". J. Exp. Med. 183 (4): 1331–8. doi:10.1084/jem.183.4.1331. PMC 2192513. PMID 8666891.
- Leta E, Hou Z, Lederman L, Jung LK (1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7.". Cell. Immunol. 173 (1): 15–21. doi:10.1006/cimm.1996.0247. PMID 8871597.
- Lee DM, Patel DD, Pendergast AM, Haynes BF (1997). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.". Int. Immunol. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Slentz-Kesler KA, Hale LP, Kaufman RE (1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.". Genomics 47 (3): 327–40. doi:10.1006/geno.1997.5151. PMID 9480746.
- Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family.". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- Pace KE, Lee C, Stewart PL, Baum LG (1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.". J. Immunol. 163 (7): 3801–11. PMID 10490978.
- Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.". J. Biol. Chem. 275 (5): 3431–7. doi:10.1074/jbc.275.5.3431. PMID 10652336.
- Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
- Rossi MI, Yokota T, Medina KL, Garrett KP, Comp PC, Schipul AH et al. (2003). "B lymphopoiesis is active throughout human life, but there are developmental age-related changes.". Blood 101 (2): 576–84. doi:10.1182/blood-2002-03-0896. PMID 12393702.
External links
- CD7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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