CD247

CD247 molecule

PDB rendering based on 2hac.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCD247 ; CD3-ZETA; CD3H; CD3Q; CD3Z; T3Z; TCRZ
External IDsOMIM: 186780 MGI: 88334 HomoloGene: 12818 GeneCards: CD247 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez91912503
EnsemblENSG00000198821ENSMUSG00000005763
UniProtP20963P24161
RefSeq (mRNA)NM_000734NM_001113391
RefSeq (protein)NP_000725NP_001106862
Location (UCSC)Chr 1:
167.4 – 167.49 Mb		Chr 1:
165.79 – 165.88 Mb
PubMed search

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.[1]

Genomics

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function

T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

Interactions

CD247 has been shown to interact with Janus kinase 3[3] and Protein unc-119 homolog.[4]

See also

References

  1. ↑ Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ et al. (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. doi:10.1073/pnas.85.24.9709. PMC 282845. PMID 2974162.
  2. ↑ "Entrez Gene: CD247 CD247 molecule".
  3. ↑ Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H et al. (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.
  4. ↑ Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.

Further reading

External links