CD109
| CD109 molecule | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CD109 ; CPAMD7; p180; r150 | ||||||||||||
| External IDs | OMIM: 608859 MGI: 2445221 HomoloGene: 25183 GeneCards: CD109 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 135228 | 235505 | |||||||||||
| Ensembl | ENSG00000156535 | ENSMUSG00000046186 | |||||||||||
| UniProt | Q6YHK3 | Q8R422 | |||||||||||
| RefSeq (mRNA) | NM_001159587 | NM_153098 | |||||||||||
| RefSeq (protein) | NP_001153059 | NP_694738 | |||||||||||
| Location (UCSC) | Chr 6: 74.41 – 74.54 Mb | Chr 9: 78.62 – 78.72 Mb | |||||||||||
| PubMed search | |||||||||||||
CD109 (Cluster of Differentiation 109) is a human gene.[1]
CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM][1]
See also
References
Further reading
- Lucas GF, Metcalfe P (2000). "Platelet and granulocyte glycoprotein polymorphisms.". Transfusion medicine (Oxford, England) 10 (3): 157–74. doi:10.1046/j.1365-3148.2000.00250.x. PMID 10972910.
- Sutherland DR, Yeo E, Ryan A et al. (1991). "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets.". Blood 77 (1): 84–93. PMID 1984805.
- Kelton JG, Smith JW, Horsewood P et al. (1990). "Gova/b alloantigen system on human platelets.". Blood 75 (11): 2172–6. PMID 2346781.
- Lin M, Sutherland DR, Horsfall W et al. (2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins.". Blood 99 (5): 1683–91. doi:10.1182/blood.V99.5.1683. PMID 11861284.
- Schuh AC, Watkins NA, Nguyen Q et al. (2002). "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.". Blood 99 (5): 1692–8. doi:10.1182/blood.V99.5.1692. PMID 11861285.
- Giesert C, Marxer A, Sutherland DR et al. (2003). "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets.". Ann. N. Y. Acad. Sci. 996: 227–30. doi:10.1111/j.1749-6632.2003.tb03250.x. PMID 12799300.
- Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Solomon KR, Sharma P, Chan M et al. (2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family.". Gene 327 (2): 171–83. doi:10.1016/j.gene.2003.11.025. PMID 14980714.
- Zhang JM, Hashimoto M, Kawai K et al. (2005). "CD109 expression in squamous cell carcinoma of the uterine cervix.". Pathol. Int. 55 (4): 165–9. doi:10.1111/j.1440-1827.2005.01807.x. PMID 15826242.
- Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell Proteomics 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
- Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Finnson KW, Tam BY, Liu K et al. (2006). "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes". FASEB J. 20 (9): 1525–7. doi:10.1096/fj.05-5229fje. PMID 16754747.
- Sjöblom T, Jones S, Wood LD et al. (2006). "The consensus coding sequences of human breast and colorectal cancers". Science 314 (5797): 268–74. doi:10.1126/science.1133427. PMID 16959974.
- Hasegawa M, Hagiwara S, Sato T et al. (2007). "CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells". Pathol. Int. 57 (5): 245–50. doi:10.1111/j.1440-1827.2007.02097.x. PMID 17493171.
External links
- CD109 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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