CCT3
T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.[1][2]
This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
Interactions
CCT3 has been shown to interact with PPP4C.[3][4]
References
- ↑ Joly EC, Sevigny G, Todorov IT, Bibor-Hardy V (March 1994). "cDNA encoding a novel TCP1-related protein". Biochim Biophys Acta 1217 (2): 224–6. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.
- ↑ 2.0 2.1 "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)".
- ↑ Chen, Ginny I; Tisayakorn Sally, Jorgensen Claus, D'Ambrosio Lisa M, Goudreault Marilyn, Gingras Anne-Claude (October 2008). "PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4". J. Biol. Chem. (United States) 283 (43): 29273–84. doi:10.1074/jbc.M803443200. ISSN 0021-9258. PMC 2662017. PMID 18715871.
- ↑ Gingras, Anne-Claude; Caballero Michael; Zarske Marcel; Sanchez Amy; Hazbun Tony R; Fields Stanley; Sonenberg Nahum; Hafen Ernst; Raught Brian; Aebersold Ruedi (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell Proteomics (United States) 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. ISSN 1535-9476. PMID 16085932.
Further reading
- Kubota H, Hynes G, Carne A et al. (1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Curr. Biol. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
- Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N (1995). "Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization". Genomics 22 (3): 634–6. doi:10.1006/geno.1994.1438. PMID 8001976.
- Walkley NA, Demaine AG, Malik AN (1996). "Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma". Biochem. J. 313 ( Pt 2) (Pt 2): 381–9. PMC 1216920. PMID 8573069.
- Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J (2000). "Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC". Mol. Cell 4 (6): 1051–61. doi:10.1016/S1097-2765(00)80233-6. PMID 10635329.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wong N, Chan A, Lee SW et al. (2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". J. Hepatol. 38 (3): 298–306. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
- Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- Reuter TY, Medhurst AL, Waisfisz Q et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
- Imai Y, Soda M, Murakami T et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
| |||||||||||
