CBY1
| Chibby homolog 1 (Drosophila) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CBY1 ; C22orf2; CBY; HS508I15A; PGEA1; PIGEA-14; PIGEA14; arb1 | ||||||||||||
| External IDs | OMIM: 607757 MGI: 1920989 HomoloGene: 12514 GeneCards: CBY1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 25776 | 73739 | |||||||||||
| Ensembl | ENSG00000100211 | ENSMUSG00000022428 | |||||||||||
| UniProt | Q9Y3M2 | Q9D1C2 | |||||||||||
| RefSeq (mRNA) | NM_001002880 | NM_028634 | |||||||||||
| RefSeq (protein) | NP_001002880 | NP_082910 | |||||||||||
| Location (UCSC) | Chr 22: 39.05 – 39.07 Mb | Chr 15: 79.66 – 79.67 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.[1][2][3]
Function
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[3]
Interactions
CBY1 has been shown to interact with Beta-catenin.[4]
References
- ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- ↑ Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699. Vancouver style error (help)
- ↑ 3.0 3.1 "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)".
- ↑ Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.
Further reading
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H et al. (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
- Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
- Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.
- Gad S, Teboul D, Lièvre A, Goasguen N, Berger A, Beaune P et al. (2004). "Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?". BMC Cancer 4: 31. doi:10.1186/1471-2407-4-31. PMC 471554. PMID 15245581. Vancouver style error (help)
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Schuierer MM, Graf E, Takemaru K, Dietmaier W, Bosserhoff AK (2006). "Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines". World J. Gastroenterol. 12 (10): 1529–35. PMID 16570344.
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. Vancouver style error (help)
- Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT et al. (2007). "Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling". Mol. Cell. Biol. 27 (12): 4347–54. doi:10.1128/MCB.01640-06. PMC 1900052. PMID 17403895.