CARD11
Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein that in humans is encoded by the CARD11 gene.[1][2][3]
Function
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activates NF-kappaB and induces the phosphorylation of BCL10.[3]
Interactions
CARD11 has been shown to interact with BCL10.[4]
References
- ↑ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM et al. (Apr 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
- ↑ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2-3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
- ↑ 3.0 3.1 "Entrez Gene: CARD11 caspase recruitment domain family, member 11".
- ↑ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM et al. (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
Further reading
- Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
- Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS et al. (2002). "A requirement for CARMA1 in TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 830–5. doi:10.1038/ni824. PMID 12154356.
- Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S et al. (2002). "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 836–43. doi:10.1038/ni830. PMID 12154360.
- Pomerantz JL, Denny EM, Baltimore D (2002). "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex". EMBO J. 21 (19): 5184–94. doi:10.1093/emboj/cdf505. PMC 129028. PMID 12356734.
- Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL et al. (2004). "CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1". Mol. Cell. Biol. 24 (1): 164–71. doi:10.1128/MCB.24.1.164-171.2003. PMC 303359. PMID 14673152.
- Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A et al. (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
- Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S (2005). "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science 308 (5718): 114–8. doi:10.1126/science.1107107. PMID 15802604.
- Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H et al. (2005). "PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1". J. Exp. Med. 202 (10): 1423–31. doi:10.1084/jem.20051591. PMC 2212994. PMID 16301747.
- Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL et al. (2005). "Phosphorylation of the CARMA1 linker controls NF-kappaB activation". Immunity 23 (6): 561–74. doi:10.1016/j.immuni.2005.09.014. PMID 16356855. Vancouver style error (help)
- Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B et al. (2005). "Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation". Immunity 23 (6): 575–85. doi:10.1016/j.immuni.2005.10.007. PMID 16356856.
- Narayan P, Holt B, Tosti R, Kane LP (2006). "CARMA1 is required for Akt-mediated NF-kappaB activation in T cells". Mol. Cell. Biol. 26 (6): 2327–36. doi:10.1128/MCB.26.6.2327-2336.2006. PMC 1430296. PMID 16508008.
- Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H et al. (2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMC 3204664. PMID 16520020.
- Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A et al. (2006). "Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation". Mol. Cell. Biol. 26 (14): 5497–508. doi:10.1128/MCB.02469-05. PMC 1592706. PMID 16809782.