CALM2
| Calmodulin 2 (phosphorylase kinase, delta) |
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PDB rendering based on 1a29. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1AJI, 1CDL, 1CLL, 1CTR, 1IWQ, 1J7O, 1J7P, 1K90, 1K93, 1L7Z, 1LVC, 1NKF, 1PK0, 1S26, 1SK6, 1SW8, 1WRZ, 1XFU, 1XFV, 1XFW, 1XFX, 1XFY, 1XFZ, 1Y6W, 1YR5, 1YRT, 1YRU, 1ZOT, 1ZUZ, 2BE6, 2F3Y, 2F3Z, 2HF5, 2I08, 2JZI, 2K0E, 2K0F, 2K0J, 2K61, 2KNE, 2KUG, 2KUH, 2L53, 2L7L, 2LGF, 2LL6, 2LL7, 2LQC, 2LQP, 2LV6, 2M0J, 2M0K, 2M55, 2MG5, 2R28, 2V01, 2V02, 2VAY, 2W73, 2WEL, 2X0G, 2Y4V, 3BYA, 3DVE, 3DVJ, 3DVK, 3DVM, 3EWT, 3EWV, 3G43, 3HR4, 3J41, 3O77, 3O78, 3OXQ, 3SUI, 3UCT, 3UCW, 3UCY, 4BW7, 4BW8, 4BYF, 4DCK, 4DJC, 4GOW, 4JPZ, 4JQ0, 4L79, 4LZX, 4M1L
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| Identifiers |
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| Symbols | CALM2 ; CAMII; PHKD; PHKD2 |
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| External IDs | OMIM: 114182 MGI: 103250 HomoloGene: 134804 GeneCards: CALM2 Gene |
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| EC number | 2.7.11.19 |
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| Orthologs |
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| Species | Human | Mouse | |
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| Entrez | 805 | 640703 | |
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| Ensembl | ENSG00000143933 | ENSMUSG00000036438 | |
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| UniProt | P62158 | P62204 | |
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| RefSeq (mRNA) | NM_001743 | NM_007589 | |
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| RefSeq (protein) | NP_001734 | NP_031615 | |
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| Location (UCSC) | Chr 14:
90.4 – 90.41 Mb | Chr 17:
87.83 – 87.85 Mb | |
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| PubMed search | | | |
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Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene.[1][2]
Clinical significance
Mutations in CALM2 are associated to cardiac arrhythmias .[3]
Interactions
CALM2 has been shown to interact with AKAP9.[4][5]
See also
References
- ↑ "Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)".
- ↑ SenGupta B, Friedberg F, Detera-Wadleigh SD (December 1987). "Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species". J. Biol. Chem. 262 (34): 16663–70. PMID 2445749.
- ↑ Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS et al. (2014). "Novel calmodulin mutations associated with congenital arrhythmia susceptibility". Circ Cardiovasc Genet 7 (4): 466–74. doi:10.1161/CIRCGENETICS.113.000459. PMC 4140998. PMID 24917665.
- ↑ Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (Sep 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
- ↑ Berchtold MW, Egli R, Rhyner JA, Hameister H, Strehler EE (May 1993). "Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3". Genomics 16 (2): 461–5. doi:10.1006/geno.1993.1211. PMID 8314583.
Further reading
- Zhang M, Yuan T (1998). "Molecular mechanisms of calmodulin's functional versatility". Biochem. Cell Biol. 76 (2-3): 313–23. doi:10.1139/bcb-76-2-3-313. PMID 9923700.
- Gusev NB (2001). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation". Biochemistry Mosc. 66 (10): 1112–21. doi:10.1023/A:1012480829618. PMID 11736632.
- Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications". Eur. J. Biochem. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
- Koller M, Schnyder B, Strehler EE (1990). "Structural organization of the human CaMIII calmodulin gene". Biochim. Biophys. Acta 1087 (2): 180–9. doi:10.1016/0167-4781(90)90203-e. PMID 2223880.
- Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD (1987). "Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C". Biochemistry 26 (10): 2886–93. doi:10.1021/bi00384a033. PMID 3111527.
- Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
- Srinivas SK, Srinivas RV, Anantharamaiah GM, Compans RW, Segrest JP (1993). "Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins". J. Biol. Chem. 268 (30): 22895–9. PMID 8226798.
- Miller MA, Mietzner TA, Cloyd MW, Robey WG, Montelaro RC (1993). "Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein". AIDS Res. Hum. Retroviruses 9 (11): 1057–66. doi:10.1089/aid.1993.9.1057. PMID 8312049.
- Radding W, Pan ZQ, Hunter E, Johnston P, Williams JP, McDonald JM (1996). "Expression of HIV-1 envelope glycoprotein alters cellular calmodulin". Biochem. Biophys. Res. Commun. 218 (1): 192–7. doi:10.1006/bbrc.1996.0034. PMID 8573130.
- Pan Z, Radding W, Zhou T, Hunter E, Mountz J, McDonald JM (1996). "Role of calmodulin in HIV-potentiated Fas-mediated apoptosis". Am. J. Pathol. 149 (3): 903–10. PMC 1865159. PMID 8780394.
- Sasaki M, Uchiyama J, Ishikawa H, Matsushita S, Kimura G, Nomoto K et al. (1996). "Induction of apoptosis by calmodulin-dependent intracellular Ca2+ elevation in CD4+ cells expressing gp 160 of HIV". Virology 224 (1): 18–24. doi:10.1006/viro.1996.0502. PMID 8862395.
- Brigino E, Haraguchi S, Koutsonikolis A, Cianciolo GJ, Owens U, Good RA et al. (1997). "Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3178–82. doi:10.1073/pnas.94.7.3178. PMC 20342. PMID 9096366.
- Minakami R, Jinnai N, Sugiyama H (1997). "Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro". J. Biol. Chem. 272 (32): 20291–8. doi:10.1074/jbc.272.32.20291. PMID 9242710.
- Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M et al. (1997). "Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin". Nature 388 (6645): 882–7. doi:10.1038/42264. PMID 9278050.
- Malvoisin E, Wild F (1997). "Inhibition of HIV-1, HIV-2 and SIV envelope glycoprotein-mediated cell fusion by calmodulin". Virus Res. 50 (2): 119–27. doi:10.1016/S0168-1702(97)00060-9. PMID 9282777.
- Martoglio B, Graf R, Dobberstein B (1997). "Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin". EMBO J. 16 (22): 6636–45. doi:10.1093/emboj/16.22.6636. PMC 1170268. PMID 9362478.
- Ishikawa H, Sasaki M, Noda S, Koga Y (1998). "Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin". J. Virol. 72 (8): 6574–80. PMC 109834. PMID 9658102.
- Toutenhoofd SL, Foletti D, Wicki R, Rhyner JA, Garcia F, Tolon R et al. (1998). "Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3". Cell Calcium 23 (5): 323–38. doi:10.1016/S0143-4160(98)90028-8. PMID 9681195.
PDB gallery |
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| | 1a29: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX) |
| 1ahr: CALMODULIN MUTANT WITH A TWO RESIDUE DELETION IN THE CENTRAL HELIX |
| 1ak8: NMR SOLUTION STRUCTURE OF CERIUM-LOADED CALMODULIN AMINO-TERMINAL DOMAIN (CE2-TR1C), 23 STRUCTURES |
| 1cdl: TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX |
| 1cdm: MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES |
| 1cfc: CALCIUM-FREE CALMODULIN |
| 1cfd: CALCIUM-FREE CALMODULIN |
| 1cff: NMR SOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THE CA2+-PUMP |
| 1ckk: CALMODULIN/RAT CA2+/CALMODULIN DEPENDENT PROTEIN KINASE FRAGMENT |
| 1cll: CALMODULIN STRUCTURE REFINED AT 1.7 ANGSTROMS RESOLUTION |
| 1cm1: MOTIONS OF CALMODULIN-SINGLE-CONFORMER REFINEMENT |
| 1cm4: MOTIONS OF CALMODULIN-FOUR-CONFORMER REFINEMENT |
| 1cmf: NMR SOLUTION STRUCTURE OF APO CALMODULIN CARBOXY-TERMINAL DOMAIN |
| 1cmg: NMR SOLUTION STRUCTURE OF CALCIUM-LOADED CALMODULIN CARBOXY-TERMINAL DOMAIN |
| 1ctr: DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX |
| 1deg: THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE |
| 1dmo: CALMODULIN, NMR, 30 STRUCTURES |
| 1f70: REFINED SOLUTION STRUCTURE OF CALMODULIN N-TERMINAL DOMAIN |
| 1f71: REFINED SOLUTION STRUCTURE OF CALMODULIN C-TERMINAL DOMAIN |
| 1fw4: CRYSTAL STRUCTURE OF E. COLI FRAGMENT TR2C FROM CALMODULIN TO 1.7 A RESOLUTION |
| 1g4y: 1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN |
| 1iq5: Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment |
| 1iwq: Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin |
| 1j7o: Solution structure of Calcium-calmodulin N-terminal domain |
| 1j7p: Solution structure of Calcium calmodulin C-terminal domain |
| 1k90: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP |
| 1k93: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin |
| 1l7z: Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide |
| 1lin: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX) |
| 1lvc: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP |
| 1mux: SOLUTION NMR STRUCTURE OF CALMODULIN/W-7 COMPLEX: THE BASIS OF DIVERSITY IN MOLECULAR RECOGNITION, 30 STRUCTURES |
| 1mxe: Structure of the Complex of Calmodulin with the Target Sequence of CaMKI |
| 1niw: Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin |
| 1nwd: Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia Glutamate Decarboxylase |
| 1ooj: Structural genomics of Caenorhabditis elegans : Calmodulin |
| 1pk0: Crystal Structure of the EF3-CaM complexed with PMEApp |
| 1prw: Crystal structure of bovine brain Ca++ calmodulin in a compact form |
| 1qiv: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX |
| 1qiw: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD) |
| 1qs7: The 1.8 angstrom structure of calmodulin rs20 peptide complex |
| 1qtx: THE 1.65 ANGSTROM STRUCTURE OF CALMODULIN RS20 PEPTIDE COMPLEX |
| 1qx5: Crystal structure of apoCalmodulin |
| 1qx7: Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel |
| 1s26: Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex Reveals an Alternative Mode of ATP Binding to the Catalytic Site |
| 1sk6: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate |
| 1sw8: Solution structure of the N-terminal domain of Human N60D calmodulin refined with paramagnetism based strategy |
| 1sy9: Structure of calmodulin complexed with a fragment of the olfactory CNG channel |
| 1vrk: THE 1.9 ANGSTROM STRUCTURE OF E84K-CALMODULIN RS20 PEPTIDE COMPLEX |
| 1wrz: Calmodulin complexed with a peptide from a human death-associated protein kinase |
| 1x02: Solution structure of stereo array isotope labeled (SAIL) calmodulin |
| 1xa5: Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid |
| 1xfu: Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin |
| 1xfv: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP |
| 1xfw: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP) |
| 1xfx: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride |
| 1xfy: Crystal structure of anthrax edema factor (EF) in complex with calmodulin |
| 1xfz: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride |
| 1y0v: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate |
| 1y6w: Trapped intermediate of calmodulin |
| 1yr5: 1.7-A structure of calmodulin bound to a peptide from DAP kinase |
| 1yrt: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin |
| 1yru: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride |
| 1zot: crystal structure analysis of the CyaA/C-Cam with PMEAPP |
| 1zuz: Calmodulin in complex with a mutant peptide from human DRP-1 kinase |
| 2bbm: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR |
| 2bbn: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR |
| 2bcx: Crystal structure of calmodulin in complex with a ryanodine receptor peptide |
| 2be6: 2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex |
| 2bkh: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2) CRYSTAL STRUCTURE |
| 2bki: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2-IQ) CRYSTAL STRUCTURE |
| 2col: Crystal structure analysis of CyaA/C-Cam with Pyrophosphate |
| 2dfs: 3-D structure of Myosin-V inhibited state |
| 2f2o: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode |
| 2f2p: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode |
| 2f3y: Calmodulin/IQ domain complex |
| 2f3z: Calmodulin/IQ-AA domain complex |
| 2fot: Crystal structure of the complex between calmodulin and alphaII-spectrin |
| 2hf5: The structure and function of a novel two-site calcium-binding fragment of calmodulin |
| 2ix7: STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V |
| 3cln: STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION |
| 4cln: STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTION |
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