CA11

Carbonic anhydrase XI
Identifiers
SymbolsCA11 ; CARPX1
External IDsOMIM: 604644 MGI: 1336193 HomoloGene: 36061 ChEMBL: 2420 GeneCards: CA11 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez77012348
EnsemblENSG00000063180ENSMUSG00000003273
UniProtO75493O70354
RefSeq (mRNA)NM_001217NM_009800
RefSeq (protein)NP_001208NP_033930
Location (UCSC)Chr 19:
49.14 – 49.15 Mb
Chr 7:
45.7 – 45.7 Mb
PubMed search

Carbonic anhydrase-related protein 11 is an enzyme that in humans is encoded by the CA11 gene.[1][2]

Function

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.[2]

Interactions

CA11 has been shown to interact with RIPK1.[3]

References

  1. Lovejoy DA, Hewett-Emmett D, Porter CA, Cepoi D, Sheffield A, Vale WW et al. (Feb 1999). "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3". Genomics 54 (3): 484–93. doi:10.1006/geno.1998.5585. PMID 9878252. Check date values in: |year= / |date= mismatch (help)
  2. 2.0 2.1 "Entrez Gene: CA11 carbonic anhydrase XI".
  3. Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S et al. (May 2008). "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation". Curr. Biol. 18 (9): 641–9. doi:10.1016/j.cub.2008.04.017. PMC 2587165. PMID 18450452.

Further reading