Bruce Ponder

Bruce Ponder
Nationality British
Institutions University of Cambridge
Thesis The Nucleoprotein Complexes of Polyoma Virus (1977)
Doctoral advisor Lionel Crawford
Notable awards
Website
www.oncology.cam.ac.uk/research/groupleaders/ponder.html

Professor Sir Bruce Anthony John Ponder is Professor of Oncology at the University of Cambridge and former director of the Cancer Research UK Cambridge Research Institute. Ponder's team helped to identify the breast cancer susceptibility genes BRCA1 and BRCA2.[1][2][3][4][5][6][7]

Education

He carried out his PhD studies with Lionel Crawford in London working on chromatin organisation and DNA sequence specificity using polyoma virus.[8]

Awards and honours

In 1997 Ponder delivered the Croonian Lecture to the Royal College of Physicians on the subject of the RET gene.[9] He was elected a Fellow of the Royal Society in 2001,[10] he was knighted for Services to Medicine in the 2008 New Year’s Honours list,[11] and was awarded the 2013 Cancer Research UK Lifetime Achievement Prize.[12] His nomination for the Royal Society reads:

“ Bruce Ponder is distinguished for his contributions to human cancer genetics and is a leader in the international collaborations which have led to the identification of genes predisposing for breast and ovarian cancer. His fundamental work on the intestine has underpinned subsequent studies of tumours in the intestinal epithelium.[13] ”

References

  1. ↑ Wooster, R.; Bignell, G.; Lancaster, J.; Swift, S.; Seal, S.; Mangion, J.; Collins, N.; Gregory, S.; Gumbs, C.; Micklem, G.; Barfoot, R.; Hamoudi, R.; Patel, S.; Rices, C.; Biggs, P.; Hashim, Y.; Smith, A.; Connor, F.; Arason, A.; Gudmundsson, J.; Ficenec, D.; Kelsell, D.; Tonin, P.; Timothy Bishop, D.; Spurr, N. K.; Ponder, B. A. J.; Eeles, R.; Peto, J.; Devilee, P.; Cornelisse, C. (1995). "Identification of the breast cancer susceptibility gene BRCA2". Nature 378 (6559): 789–792. doi:10.1038/378789a0. PMID 8524414.
  2. ↑ Antoniou, A. C.; Pharoah, P. D.; McMullan, G; Day, N. E.; Stratton, M. R.; Peto, J; Ponder, B. J.; Easton, D. F. (2002). "A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes". British Journal of Cancer 86 (1): 76–83. doi:10.1038/sj.bjc.6600008. PMC 2746531. PMID 11857015.
  3. ↑ Auranen, A; Song, H; Waterfall, C; Dicioccio, R. A.; Kuschel, B; Kjaer, S. K.; Hogdall, E; Hogdall, C; Stratton, J; Whittemore, A. S.; Easton, D. F.; Ponder, B. A.; Novik, K. L.; Dunning, A. M.; Gayther, S; Pharoah, P. D. (2005). "Polymorphisms in DNA repair genes and epithelial ovarian cancer risk". International Journal of Cancer 117 (4): 611–8. doi:10.1002/ijc.21047. PMID 15924337.
  4. ↑ Antoniou, A. C.; Pharoah, P. D.; McMullan, G; Day, N. E.; Stratton, M. R.; Peto, J; Ponder, B. J.; Easton, D. F. (2002). "A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes". British Journal of Cancer 86 (1): 76–83. doi:10.1038/sj.bjc.6600008. PMC 2746531. PMID 11857015.
  5. ↑ Antoniou, A. C.; Gayther, S. A.; Stratton, J. F.; Ponder, B. A.; Easton, D. F. (2000). "Risk models for familial ovarian and breast cancer". Genetic Epidemiology 18 (2): 173–90. doi:10.1002/(SICI)1098-2272(200002)18:2<173::AID-GEPI6>3.0.CO;2-R. PMID 10642429.
  6. ↑ Stratton, J. F.; Thompson, D; Bobrow, L; Dalal, N; Gore, M; Bishop, D. T.; Scott, I; Evans, G; Daly, P; Easton, D. F.; Ponder, B. A. (1999). "The genetic epidemiology of early-onset epithelial ovarian cancer: A population-based study". The American Journal of Human Genetics 65 (6): 1725–32. doi:10.1086/302671. PMC 1288384. PMID 10577927.
  7. ↑ Stratton, J. F.; Buckley, C. H.; Lowe, D; Ponder, B. A. (1999). "Comparison of prophylactic oophorectomy specimens from carriers and noncarriers of a BRCA1 or BRCA2 gene mutation. United Kingdom Coordinating Committee on Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group". Journal of the National Cancer Institute 91 (7): 626–8. PMID 10203282.
  8. ↑ Ponder, B. A.; Crew, F; Crawford, L. V. (1978). "Comparison of nuclease digestion of polyoma virus nucleoprotein complex and mouse chromatin". Journal of virology 25 (1): 175–86. PMC 353914. PMID 202734.
  9. ↑ "Croonian Lectures (Sadleir Trust)". Royal College of Physicians. Retrieved 2012-099-07. Check date values in: |accessdate= (help)
  10. ↑ "Fellows of the Royal Society". Royal Society. Retrieved 2012-08-02.
  11. ↑ "Professor Sir Bruce Ponder FRS, Department Head and Director of the Cambridge Cancer Centre, University of Cambridge". research-europe.com. Archived from the original on 2015-02-11.
  12. ↑ https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/our-research-prizes
  13. ↑ "EC/2001/28: Ponder, Bruce Anthony John". London: The Royal Society. Archived from the original on 2015-04-11.