Borna disease

Bornavirus
Virus classification
Group: Group V ((-)ssRNA)
Order: Mononegavirales
Family: Bornaviridae
Genus: Bornavirus
Species

Borna disease virus

Borna disease virus
Classification and external resources
ICD-9 062.9
DiseasesDB 1529
MeSH D001890

Borna disease is an infectious neurological syndrome[1] of warm-blooded animals, caused by Borna disease virus (BDV), which causes abnormal behaviour and fatality. The Borna disease virus is a neurotropic virus and is a member of the Bornaviridae family within the Mononegavirales order.

Although the Borna disease virus is mainly seen as the causative agent of borna disease in horses and other animals, it also infects humans and is therefore considered to be a zoonotic agent. The role of BDV in human illness is controversial and it is yet to be established whether BDV causes any overt disease in humans. However, correlative evidence exists linking BDV infection with neuropsychiatric disorders such as bipolar disorder.[2]

Epidemiology

Vectors

The mode of transmission of BDV is unclear but probably occurs through intranasal exposure to contaminated saliva or nasal secretions. Following infection, individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus.

Animals

Borna virus appears to have a wide host range, having been detected in horses, cattle, sheep, dogs and foxes. In 1995, the virus was isolated from cats suffering from a "staggering disease" in Sweden. Since that time, the virus has also been detected in cats in Japan and Britain.

Borna virus has been detected in humans, and researchers have presented evidence connecting these infections with psychiatric disorders.[3][4][5]

Experimental infection of rats has been demonstrated to lead to learning impairments and altered social behaviour. The virus appears to be distributed primarily in the limbic system of the brain, including the hippocampus and entorhinal cortex. These areas of the brain are considered to be of importance in emotion.

Originally identified in sheep and horses[6] in Europe, it has since been found to occur in a wide range of warm-blooded animals including birds, cattle, cats[7] and primates and has been found in animals in Europe, Asia, Africa and North America. The name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in 1885.

Avian Bornaviruses (ABV), a group of related viruses, have been reported, yet not proven, as the cause of Proventricular Dilatation Disease (PDD), a disease of pet parrots. The use of a 'positive' brain cell culture containing ABV to inoculate another psittacine (parrot) bird resulted in the inoculated bird's death and subsequent histopathological diagnosis of PDD (mononuclear infiltrative ganglioneuritis). Earlier research with purified inoculant of ABV (while did result in the death of parrots) did not reproduce histopathological changes associated with PDD.

Borna disease in sheep and horses arises after a four week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis. Clinical manifestations vary but may include excited or depressed behaviour, ataxia, ocular disorders and abnormal posture and movement. Mortality rates are 80-100% in horses and greater than 50% in sheep.

Borna disease in the horse gives rise to signs like:

History

The first antibodies to Borna virus in humans were discovered in the mid-1980s. Since then, there have been conflicting results from various studies in regards to whether an association exists between the agent and clinical disease. Antibodies to Borna virus, which indicate prior infection, and Borna virus antigen have also been detected in blood donors.

Psychiatric disease

There is some evidence that there may be a relationship between Borna virus infection and psychiatric disease.[3][4]

In 1990, Janice E. Clements and colleagues reported in the journal Science that antibodies to a protein encoded by the Borna virus genome are found in the blood of patients with behavioral disorders.[5] In the early 1990s, researchers in Germany, America, and Japan conducted an investigation of 5000 patients with psychiatric disorders and 1000 controls, in which a significantly higher percentage of patients than controls were positive for BDV antibodies.[5] Subsequent studies have also presented evidence for an association between Borna and human psychiatric disorders.[8][9][10] However, not all researchers consider the link between Borna virus and human psychiatric disease to be conclusively proven. A recent study found no Borna virus antibodies in 62 patients with the deficit form of schizophrenia.[11]

Additional evidence for a role of Borna virus in psychiatric disorders comes from reports that the drug amantadine, which is used to treat influenza infections, has had some success in treating depression and clearing Borna infection.[12] Counter-claims state that Borna virus infections are not cleared by amantadine. The issue is further complicated by the fact that amantadine is also used in the treatment of Parkinson's disease and may have direct effects on the nervous system.

References

  1. ↑ Ackermann A, Staeheli P, Schneider U (August 2007). "Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity". J. Virol. 81 (15): 7933–40. doi:10.1128/JVI.00334-07. PMC 1951315. PMID 17522214.
  2. ↑ "(Quoted) Liv Bode - Robert Koch Institute, Ron Ferszt - Free University of Berlin" (August 31, 1998). "Research suggests virus may play role in depression". CNN Health.
  3. ↑ 3.0 3.1 Bode L, Ludwig H (July 2003). "Borna disease virus infection, a human mental-health risk". Clin. Microbiol. Rev. 16 (3): 534–45. doi:10.1128/CMR.16.3.534-545.2003. PMC 164222. PMID 12857781.
  4. ↑ 4.0 4.1 VandeWoude S, Richt JA, Zink MC, Rott R, Narayan O, Clements JE (November 1990). "A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases". Science 250 (4985): 1278–81. doi:10.1126/science.2244211. PMID 2244211.
  5. ↑ 5.0 5.1 5.2 Rott R, Herzog S, Bechter K, Frese K (1991). "Borna disease, a possible hazard for man?". Archives of Virology 118 (3-4): 143–9. doi:10.1007/BF01314025. PMID 2069502.
  6. ↑ Dauphin G, Legay V, Pitel PH, Zientara S (2002). "Borna disease: current knowledge and virus detection in France". Vet. Res. 33 (2): 127–38. doi:10.1051/vetres:2002002. PMID 11944803.
  7. ↑ Kamhieh S, Flower RL (June 2006). "Borna disease virus (BDV) infection in cats. A concise review based on current knowledge". Vet Q 28 (2): 66–73. doi:10.1080/01652176.2006.9695210. PMID 16841569.
  8. ↑ Miranda HC, Nunes SO, Calvo ES, Suzart S, Itano EN, Watanabe MA (January 2006). "Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients". J Affect Disord 90 (1): 43–7. doi:10.1016/j.jad.2005.10.008. PMID 16324750.
  9. ↑ Fukuda K, Takahashi K, Iwata Y et al. (February 2001). "Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan". J. Clin. Microbiol. 39 (2): 419–29. doi:10.1128/JCM.39.2.419-429.2001. PMC 87754. PMID 11158085.
  10. ↑ Waltrip RW, Buchanan RW, Carpenter WT et al. (February 1997). "Borna disease virus antibodies and the deficit syndrome of schizophrenia". Schizophr. Res. 23 (3): 253–7. doi:10.1016/S0920-9964(96)00114-4. PMID 9075304.
  11. ↑ "Wiley InterScience :: JOURNALS :: Acta Neuropsychiatrica". Retrieved 2009-01-20.
  12. ↑ Dietrich DE, Bode L, Spannhuth CW et al. (March 2000). "Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial". Bipolar Disord 2 (1): 65–70. doi:10.1034/j.1399-5618.2000.020110.x. PMID 11254023.