Bone morphogenetic protein 3

Not to be confused with BMP-3.
Bone morphogenetic protein 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsBMP3 ; BMP-3A
External IDsOMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez651110075
EnsemblENSG00000152785ENSMUSG00000029335
UniProtP12645Q8BHE5
RefSeq (mRNA)NM_001201NM_173404
RefSeq (protein)NP_001192NP_775580
Location (UCSC)Chr 4:
81.95 – 81.98 Mb		Chr 5:
98.85 – 98.88 Mb
PubMed search

Bone morphogenetic protein 3 is a protein in humans that is encoded by the BMP3 gene.[1]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.

References

  1. ↑ "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".

Further reading

  • Dickinson ME; Kobrin MS; Silan CM et al. (1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330.
  • Tabas JA; Zasloff M; Wasmuth JJ et al. (1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778.
  • Paralkar VM; Nandedkar AK; Pointer RH et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". J. Biol. Chem. 265 (28): 17281–4. PMID 2211625.
  • Rosen V; Wozney JM; Wang EA et al. (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connect. Tissue Res. 20 (1–4): 313–9. doi:10.3109/03008208909023902. PMID 2612162.
  • Wozney JM; Rosen V; Celeste AJ et al. (1989). "Novel regulators of bone formation: molecular clones and activities". Science 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.
  • Faucheux C; Ulysse F; Bareille R et al. (1998). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochem. Biophys. Res. Commun. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787.
  • Daluiski A; Engstrand T; Bahamonde ME et al. (2001). "Bone morphogenetic protein-3 is a negative regulator of bone density". Nat. Genet. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004.
  • Jin Y; Lu HB; Liong E et al. (2002). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histol. Histopathol. 16 (4): 1013–9. PMID 11642720.
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kloen P; Di Paola M; Borens O et al. (2004). "BMP signaling components are expressed in human fracture callus". Bone 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.
  • Kang Q; Sun MH; Cheng H et al. (2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Ther. 11 (17): 1312–20. doi:10.1038/sj.gt.3302298. PMID 15269709.
  • Chen AL; Fang C; Liu C et al. (2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". J. Orthop. Res. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196.
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.