Bone morphogenetic protein 10
Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.[1][2]
BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.[2] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.
Further reading
- Davila S; Froeling FE; Tan A et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
- Hillier LW; Graves TA; Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Mazerbourg S; Sangkuhl K; Luo CW et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Nakano N; Hori H; Abe M et al. (2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". Am. J. Physiol. Heart Circ. Physiol. 293 (6): H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333.
- Marroni F; Pfeufer A; Aulchenko YS et al. (2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circ Cardiovasc Genet 2 (4): 322–8. doi:10.1161/CIRCGENETICS.108.833806. PMC 2760953. PMID 20031603.
- Strausberg RL; Feingold EA; Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- David L; Mallet C; Mazerbourg S et al. (2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood 109 (5): 1953–61. doi:10.1182/blood-2006-07-034124. PMID 17068149.
References
- ↑ "Entrez Gene: bone morphogenetic protein 10".
- ↑ 2.0 2.1 Neuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mech. Dev. 80 (2): 181–4. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785.
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