BioGRID

BioGRID
Content
Description interaction data
Contact
Research center Université de Montréal
Laboratory Institut de Recherche en Immunologie et en Cancérologie,
Authors Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Andrew Chatr-Aryamontri, Kara Dolinski, Michael Livstone, Julie Nixon, Rose Oughtred, Jennifer Rust, Andrew Winter, Mike Tyers, Nadine Kolas
Primary citation Stark & al. (2006)[1]
Access
Website thebiogrid.org
Tools
Miscellaneous
Version 3.1.103; 1 August 2013

The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein and genetic interactions created in 2003 (originally referred to as simply the General Repository for Interaction Datasets (GRID) by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital. It strives to provide a comprehensive resource of protein–protein and genetic interactions for all major model organism species while attempting to remove redundancy to create a single mapping of interactions. Users of The BioGRID can search for their protein of interest and retrieve annotation, as well as physical and genetic interaction data as reported, by the primary literature and compiled by in house large-scale curation efforts. The BioGRID is hosted in Toronto, Ontario, Canada and is partnered with the Saccharomyces Genome Database. The BioGRID is funded by the BBSRC, NIH, and CIHR. BioGRID is a member of the International Molecular Exchange Consortium (IMEx).

BioGRID is listed in the Registry of Research Data Repositories re3data.org.[2]

History

The BioGRID was originally published and released as simply the General Repository for Interaction Datasets but was later renamed to the BioGRID in order to more concisely describe the project, and help distinguish it from several unrelated projects with a similar name. Originally separated into organism specific databases, the newest version now provides a unified front end allowing for searches across several organisms simultaneously.

Abstract

The Biological General Repository for Interaction Datasets (BioGRID) database was developed to house and distribute collections of protein and genetic interactions from major model organism species. As of 1 August 2013, BioGRID contains 703,150 interactions from 32 different species, as derived from 41,099 high-throughput and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for budding yeast (Saccharomyces cerevisiae), thale cress (Arabidopsis thaliana), and fission yeast (Schizosaccharomyces pombe). A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase, GeneDB, TAIR, and Entrez Gene. Source code for the BioGRID and the linked Osprey Network Visualization System is now freely available without restriction.

Supported Organisms

The following organisms are currently supported within the BioGRID, but not all may contain interactions in the most recent build:

References

  1. ↑ Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M (Jan 2006). "BioGRID: A General Repository for Interaction Datasets". Nucleic Acids Research 1 (34): 535–539. doi:10.1093/nar/gkj109. PMC 1347471. PMID 16381927.
  2. ↑ "BioGRID entry in re3data.org". www.re3data.org. Retrieved 20 August 2014.

Further reading

External links