Binedaline
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| Systematic (IUPAC) name | |
|---|---|
| N,N,N-trimethyl-N-(3-phenylindol-1-yl)ethane-1,2-diamine | |
| Clinical data | |
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| Oral | |
| Identifiers | |
60662-16-0  | |
| None | |
| PubChem | CID 42509 |
| ChemSpider |
38769  |
| UNII |
3AVG9P140R |
| ChEMBL |
CHEMBL2104611 |
| Chemical data | |
| Formula | C19H24ClN3 |
| 329.86696 g/mol | |
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SMILES
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| (what is this?) (verify) | |
Binedaline (Ixprim), also called binodaline, is a drug that was being investigated as an antidepressant in the 1980s but never marketed.[1][2] It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 µM) transporters.[3] It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.[3]
References
- ↑ Faltus; Geerling, F. (1984). "A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression". Neuropsychobiology 12 (1): 34–38. doi:10.1159/000118107. PMID 6239991.
- ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
- ↑ 3.0 3.1 Morin; Zini, R.; Urien, S.; Tillement, J. P. (1989). "Pharmacological profile of binedaline, a new antidepressant drug". The Journal of Pharmacology and Experimental Therapeutics 249 (1): 288–296. PMID 2540319.
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