Bifonazole

Bifonazole

Systematic (IUPAC) name
(RS)-1-[Phenyl(4-phenylphenyl)methyl]-1H-imidazole
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	US: OTC
Routes of administration	topic
Identifiers
CAS Registry Number	60628-96-8 Y
ATC code	D01AC10
PubChem	CID 2378
DrugBank	DB04794 Y
ChemSpider	2287 Y
UNII	QYJ305Z91O Y
KEGG	D01775 Y
ChEBI	CHEBI:31286 N
ChEMBL	CHEMBL277535 Y
Chemical data
Formula	C22H18N2
Molecular mass	310.392 g/mol
SMILES n1ccn(c1)C(c3ccc(c2ccccc2)cc3)c4ccccc4
InChI InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H  Y Key:OCAPBUJLXMYKEJ-UHFFFAOYSA-N  Y
N (what is this?)  (verify)

Bifonazole is an imidazole antifungal drug. Bifonazole is marketed by Bayer under the trade mark Canespor in ointment form.

Mechanism of action

Bifonazole has dual mode of action. It blocks transformation of 24-methylendihydrolanosterol to desmethylsterol in fungi together with inhibition of HMG-CoA. This enables fungicidal properties against dermatophytes and distinguishes bifonazole from other antifungal drugs.

References