Benzthiazide

Benzthiazide

Systematic (IUPAC) name
6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	Oral
Pharmacokinetic data
Bioavailability	60 to 70%
Protein binding	30%
Half-life	5 to 15 hours
Excretion	Renal
Identifiers
CAS Registry Number	91-33-8 Y
ATC code	None
PubChem	CID 2343
DrugBank	DB00562 Y
ChemSpider	2253 Y
UNII	1TD8J48L61 Y
KEGG	D00651 Y
ChEBI	CHEBI:3047 Y
ChEMBL	CHEMBL1201039 N
Chemical data
Formula	C15H14ClN3O4S3
Molecular mass	431.94 g/mol
SMILES O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C(\N2)CSCc3ccccc3)N
InChI InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)  Y Key:NDTSRXAMMQDVSW-UHFFFAOYSA-N  Y
N (what is this?)  (verify)

Benzthiazide (BAN/INN, also known as benzothiazide; trade names Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven and others^[1]) is a thiazide diuretic used in the treatment of high blood pressure and edema. It is no longer available in the United States.

In the United Kingdom, it was also sold in combination with the potassium-sparing diuretic triamterene under the trade name Dytide.^[2] The same combination is still available in Switzerland as Dyrenium compositum.^[3]

References