Benzphetamine
 | |
 | |
| Systematic (IUPAC) name | |
|---|---|
| (2S)-N-benzyl-N-methyl-1-phenylpropan-2-amine | |
| Clinical data | |
| Trade names | Didrex |
| AHFS/Drugs.com | Consumer Drug Information |
| |
| |
| Pharmacokinetic data | |
| Protein binding | 75–99% |
| Identifiers | |
156-08-1  | |
| None | |
| PubChem | CID 5311017 |
| DrugBank |
DB00865 |
| ChemSpider |
4470556 |
| UNII |
0M3S43XK27 |
| ChEBI |
CHEBI:3044 |
| ChEMBL |
CHEMBL1201358  |
| Synonyms | N-benzyl-N-methylamphetamine |
| Chemical data | |
| Formula | C17H21N |
| 239.355 g/mol | |
|
SMILES
| |
| |
| (what is this?) (verify) | |
Benzphetamine (Didrex) is an anorectic drug marketed under this brand in the USA by Pharmacia. Benzphetamine is used as a short term adjunct in management of exogenous obesity. It is closely related to methamphetamine.
Pharmacology
Benzphetamine is a sympathomimetic amine and is classified as an anorectic. The drug's main function is to reduce appetite, which in turn reduces caloric intake. Benzphetamine may cause vivid hallucinations when abused.
Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Amphetamine and related sympathomimetic medications (such as benzphetamine) are thought to stimulate the release of norepinephrine and/or dopamine from storage sites in nerve terminals of the lateral hypothalamic feeding center, thereby producing a decrease in appetite. This release is mediated through the binding of benzphetamine to VMAT2 and inhibiting its function, causing a release of these neurotransmitters into the synaptic cleft through their reuptake transporters. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class.
Contraindications
Benzphetamine is contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyper-thyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. Benzphetamine should not be given to patients who are in an agitated state or who have a history of drug abuse.
Controlled substance classification
Benzphetamine is unique in its classification as a Schedule III drug in the United States. (Most members of the amphetamine family are classified in the more highly regulated Schedule II.) Benzphetamine is metabolized by the human body into amphetamine and methamphetamine, making it one of a number of drugs to undergo in vivo conversion to a substance of higher addiction and abuse potential.[1] Benzphetamine itself does not have as high abuse potential as its metabolites (Schedule III) because of the time necessary for the liver to metabolize it into amphetamine and methamphetamine, regardless of route of administration. This gives benzphetamine an inherent 'sustained-release' effect.
References
- ↑ Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metab. Rev. 32 (1): 15–44. doi:10.1081/DMR-100100562. PMID 10711406.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||