Batimastat
Systematic (IUPAC) name | |
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(2R,3S)-N4-Hydroxy-2-isobutyl-N1-[(2S)-1-(methylamino)-1-oxo-3-phenyl-2-propanyl]-3-[(2-thienylsulfanyl)methyl]succinamide | |
Clinical data | |
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Injection into pleural space or abdomen | |
Identifiers | |
130370-60-4 | |
None | |
PubChem | CID 5362422 |
DrugBank | DB03880 |
ChemSpider | 4515033 |
KEGG | D03061 |
ChEMBL | CHEMBL279786 |
Chemical data | |
Formula | C23H31N3O4S2 |
477.64 g/mol | |
SMILES
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Batimastat (INN/USAN, codenamed BB-94) is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. It acts as a matrix metalloproteinase inhibitor (MMPI) by mimicking natural MMPI peptides.
Batimastat was the first MMPI that went into clinical trials. First results of a Phase I trial appeared in 1994. The drug reached Phase III but was never marketed; mainly because it couldn't be administered orally (as opposed to the newer and chemically similar MMPI marimastat), and injection into the peritoneum caused peritonitis.[1]
References
- ↑ Rothenberg, M. L.; Nelson, A. R.; Hande, K. R. (1999). "New Drugs on the Horizon: Matrix Metalloproteinase Inhibitors". Stem Cells 17 (4): 237–240. doi:10.1002/stem.170237. PMID 10437989.
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".