Bark isolate
Cinnamon bark oil
Bark isolates have yielded the medicines salicylic acid (active metabolite of aspirin) and paclitaxel (Taxol). The pharmacology of bark isolates is an ongoing topic of medical research.
| Isolate |
Bark source |
Researched activity |
| Paclitaxel & taxanes |
many species of Taxus |
chemotherapeutic |
| Paeonol |
Paeonia suffruticosa root bark[1] |
various |
| Honokiol, 4-O-methylhonokiol, magnolol, obovatol |
Magnolia |
neurotrophic & anti-inflammatory |
| Salicylic acid |
Salix alba |
antipyretic, analgesic |
| Yohimbine, corynanthine, ajmalicine, rauwolscine |
west African evergreen |
MAOI, stimulant |
| beta-carbolines & harmala alkaloids |
numerous |
MAOI |
| Cinnamon |
Cinnamomum |
blood sugar stabilizer, potent antioxidant |
| Quinine, quinidine, cinchonidine, cinchonine |
Cinchona |
antipyretic, analgesic, antimalarial |
| Safrole |
Sassafras |
|
| Huáng bǎi |
Amur cork tree (Phellodendron amurense) |
TCM |
| Strictamine |
Alstonia scholaris |
|
| |
Slippery Elm (Ulmus rubra) |
demulcent |
| Geniposidic acid |
Eucommia ulmoides |
|
| N-methyltryptamine & other serotonin analogs |
numerous species from Brazil, Mexico, Taiwan |
serotonin agonist, neuroimmunologic modulator |
| Quassin |
Quassia amara |
various |
| Celastrol |
Tripterygium wilfordii root bark[2] |
various |
| Mitraphylline |
Cat's claw (Uncaria tomentosa) |
anti-inflammatory |
| Ellagic acid, rutin, gallic acid, ethyl gallate[3] |
Ailanthus altissima |
various |
| Coronaridine, voacangine, ibogamine, ibogaine, tabernanthine |
Voacanga africana, Tabernanthe iboga |
neuroimmunologic modulator |
| Tramadol |
African N. latifolia |
atypical opioid analgesic with additional serotonin-norepinephrine reuptake-inhibiting activities |
| Lapachol, quercetin |
Pau D'Arco (Handroanthus impetiginosus) |
therapeutic naphthoquinone |
| Icariin |
Eucommia |
PDE5 inhibitor |
| Baicalin |
Oroxylum indicum |
prolyl endopeptidase inhibitor |
| Incensole acetate, frankincense |
Boswellia sacra, Boswellia |
incensole is a TRPV3 agonist |
|
See also
History of aspirin
Notes
- ↑ Cai J, Chen S, Zhang W, Hu S, Lu J, Xing J et al. (2014). "Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2.". Phytomedicine 21 (7): 984–91. doi:10.1016/j.phymed.2014.02.012. PMID 24680370.
- ↑ Yang H, Chen D, Cui QC, Yuan X, Dou QP (2006). "Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.". Cancer Res 66 (9): 4758–65. doi:10.1158/0008-5472.CAN-05-4529. PMID 16651429.
- ↑ Lou KQ, Tang WZ, Wang XJ (2012). "[Study on chemical constituents from flowers of Ailanthus altissima].". Zhong Yao Cai 35 (10): 1605–7. PMID 23627124.