BTBD2
| BTB (POZ) domain containing 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbol | BTBD2 | ||||||||||||
| External IDs | OMIM: 608531 MGI: 1933831 HomoloGene: 32365 GeneCards: BTBD2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55643 | 208198 | |||||||||||
| Ensembl | ENSG00000133243 | ENSMUSG00000003344 | |||||||||||
| UniProt | Q9BX70 | E9PUS2 | |||||||||||
| RefSeq (mRNA) | NM_017797 | NM_145361 | |||||||||||
| RefSeq (protein) | NP_060267 | NP_663336 | |||||||||||
| Location (UCSC) | Chr 19: 1.99 – 2.03 Mb | Chr 10: 80.64 – 80.66 Mb | |||||||||||
| PubMed search | |||||||||||||
BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.[1][2]
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.[2]
Interactions
BTBD2 has been shown to interact with TOP1.[3]
References
- ↑ Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Feb 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene 262 (1-2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.
- ↑ 2.0 2.1 "Entrez Gene: BTBD2 BTB (POZ) domain containing 2".
- ↑ Xu, Lixin; Yang Lihong, Hashimoto Keiko, Anderson Melvin, Kohlhagen Glenda, Pommier Yves, D'Arpa Peter (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics (England) 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Xu L, Yang L, Hashimoto K et al. (2003). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I.". BMC Genomics 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yamada A, Kawano K, Koga M et al. (2003). "Gene and peptide analyses of newly defined lung cancer antigens recognized by HLA-A2402-restricted tumor-specific cytotoxic T lymphocytes.". Cancer Res. 63 (11): 2829–35. PMID 12782588.
- Xu L, Yang L, Moitra PK et al. (2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.". Exp. Cell Res. 288 (1): 84–93. doi:10.1016/S0014-4827(03)00187-3. PMID 12878161.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.