BTBD1
| BTB (POZ) domain containing 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | BTBD1 ; C15orf1; NS5ATP8 | ||||||||||||
| External IDs | OMIM: 608530 MGI: 1933765 HomoloGene: 23529 GeneCards: BTBD1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 53339 | 83962 | |||||||||||
| Ensembl | ENSG00000064726 | ENSMUSG00000025103 | |||||||||||
| UniProt | Q9H0C5 | P58544 | |||||||||||
| RefSeq (mRNA) | NM_001011885 | NM_146193 | |||||||||||
| RefSeq (protein) | NP_001011885 | NP_666305 | |||||||||||
| Location (UCSC) | Chr 15: 83.69 – 83.74 Mb | Chr 7: 81.79 – 81.83 Mb | |||||||||||
| PubMed search | |||||||||||||
BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the BTBD1 gene.[1]
Function
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]
Interactions
BTBD1 has been shown to interact with TOP1.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: BTBD1 BTB (POZ) domain containing 1".
- ↑ Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y et al. (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
Further reading
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W et al. (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. Check date values in:
|year= / |date= mismatch(help) - Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Jan 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene 262 (1-2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W et al. (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. Check date values in:
|year= / |date= mismatch(help) - Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y et al. (2003). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
- Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S et al. (Aug 2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta". Experimental Cell Research 288 (1): 84–93. doi:10.1016/S0014-4827(03)00187-3. PMID 12878161.
- Pisani DF, Cabane C, Derijard B, Dechesne CA (Nov 2004). "The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation". Cell Death and Differentiation 11 (11): 1157–65. doi:10.1038/sj.cdd.4401479. PMID 15486563. Check date values in:
|year= / |date= mismatch(help) - Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A et al. (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F et al. (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.