BNC1

Basonuclin 1

Identifiers

BNC1 ; BNC; BSN1; HsT19447

External IDs

OMIM: 601930 MGI: 1097164 HomoloGene: 31048 GeneCards: BNC1 Gene

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding transcription factor activity • metal ion binding
Cellular component	• nucleus • cytoplasm
Biological process	• transcription, DNA-templated • regulation of transcription from RNA polymerase I promoter • regulation of transcription from RNA polymerase II promoter • positive regulation of cell proliferation • epidermis development • wound healing • positive regulation of epithelial cell proliferation • chromosome organization
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000169594

ENSMUSG00000025105

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
83.92 – 83.95 Mb

Chr 7:
81.97 – 81.99 Mb

PubMed search

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene.^[1]^[2]

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.^[2]

Interactions

BNC1 has been shown to interact with PICK1.^[3]

References

↑ Tseng H, Green H (Dec 1992). "Basonuclin: a keratinocyte protein with multiple paired zinc fingers". Proc Natl Acad Sci U S A 89 (21): 10311–5. doi:10.1073/pnas.89.21.10311. PMC 50328. PMID 1332044.
↑ 2.0 2.1 "Entrez Gene: BNC1 basonuclin 1".
↑ Hruska-Hageman, Alesia M; Wemmie John A; Price Margaret P; Welsh Michael J (Feb 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. (England) 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. ISSN 0264-6021. PMC 1222326. PMID 11802773.

Further reading

Tseng H (1998). "Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation.". Front. Biosci. 3: D985–8. PMID 9727087.
Tseng H, Green H (1994). "Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.". J. Cell Biol. 126 (2): 495–506. doi:10.1083/jcb.126.2.495. PMC 2200026. PMID 8034748.
Teumer J, Tseng H, Green H (1997). "The human basonuclin gene.". Gene 188 (1): 1–7. doi:10.1016/S0378-1119(96)00659-2. PMID 9099851.
Yang Z, Gallicano GI, Yu QC, Fuchs E (1997). "An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids.". J. Cell Biol. 137 (3): 657–69. doi:10.1083/jcb.137.3.657. PMC 2139879. PMID 9151672.
Iuchi S, Green H (1997). "Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation.". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 7948–53. doi:10.1073/pnas.94.15.7948. PMC 21535. PMID 9223293.
Mahoney MG, Tang W, Xiang MM et al. (1998). "Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis.". Biol. Reprod. 59 (2): 388–94. doi:10.1095/biolreprod59.2.388. PMID 9687312.
Iuchi S, Green H (1999). "Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9628–32. doi:10.1073/pnas.96.17.9628. PMC 22260. PMID 10449744.
Tseng H, Biegel JA, Brown RS (2000). "Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes.". J. Cell. Sci. 112 Pt 18: 3039–47. PMID 10462520.
Tang W, Tseng H (1999). "A GC-rich sequence within the 5' untranslated region of human basonuclin mRNA inhibits its translation.". Gene 237 (1): 35–44. doi:10.1016/S0378-1119(99)00299-1. PMID 10524234.
Iuchi S, Easley K, Matsuzaki K et al. (2000). "Alternative subcellular locations of keratinocyte basonuclin.". Exp. Dermatol. 9 (3): 178–84. doi:10.1034/j.1600-0625.2000.009003178.x. PMID 10839715.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Chen L, Willis SN, Wei A et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
Vanhoutteghem A, Djian P (2006). "Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12423–8. doi:10.1073/pnas.0605086103. PMC 1567895. PMID 16891417.