BET1
| Bet1 golgi vesicular membrane trafficking protein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | BET1 ; HBET1 | ||||||||||||
| External IDs | OMIM: 605456 MGI: 1343104 HomoloGene: 38108 GeneCards: BET1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10282 | 12068 | |||||||||||
| Ensembl | ENSG00000105829 | ENSMUSG00000032757 | |||||||||||
| UniProt | O15155 | O35623 | |||||||||||
| RefSeq (mRNA) | NM_005868 | NM_009748 | |||||||||||
| RefSeq (protein) | NP_005859 | NP_033878 | |||||||||||
| Location (UCSC) | Chr 7: 93.59 – 93.63 Mb | Chr 6: 4.08 – 4.09 Mb | |||||||||||
| PubMed search | |||||||||||||
BET1 homolog is a protein that in humans is encoded by the BET1 gene.[1][2][3]
This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined.[3]
References
- ↑ Zhang T, Wong SH, Tang BL, Xu Y, Peter F, Subramaniam VN, Hong W (Dec 1997). "The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus". J Cell Biol 139 (5): 1157–68. doi:10.1083/jcb.139.5.1157. PMC 2140212. PMID 9382863.
- ↑ Waters MG, Pfeffer SR (Nov 1999). "Membrane tethering in intracellular transport". Curr Opin Cell Biol 11 (4): 453–9. doi:10.1016/S0955-0674(99)80065-9. PMID 10449330.
- ↑ 3.0 3.1 "Entrez Gene: BET1 BET1 homolog (S. cerevisiae)".
Further reading
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport.". J. Biol. Chem. 276 (29): 27480–7. doi:10.1074/jbc.M102786200. PMID 11323436.
- "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
- Hay JC, Hirling H, Scheller RH (1996). "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus.". J. Biol. Chem. 271 (10): 5671–9. doi:10.1074/jbc.271.10.5671. PMID 8621431.
External links
- BET1 human gene location in the UCSC Genome Browser.
- BET1 human gene details in the UCSC Genome Browser.