BCL9
B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9 gene.[1][2]
BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.[2]
Common variations in the BCL9 gene, which is in the distal area, confer risk of schizophrenia and may also be associated with bipolar disorder and major depressive disorder. [3]
Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL10, it has clinical significance in lymphoma.
Related gene problems
References
- ↑ Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ (Apr 1998). "Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21". Blood 91 (6): 1873–81. PMID 9490669.
- ↑ 2.0 2.1 "Entrez Gene: BCL9 B-cell CLL/lymphoma 9".
- ↑ Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia; Junyan Li et al.; Arch Gen Psychiatry. 2011;68(3):232-240. doi:10.1001/archgenpsychiatry.2011.1
Further reading
- Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N et al. (2000). "Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations". Leukemia 13 (12): 1975–81. doi:10.1038/sj/leu/2401587. PMID 10602418.
- Kramps T, Peter O, Brunner E et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex". Cell 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446.
- Knoll A, Dvorák J, Rohrer GA, Cepica S (2002). "Linkage and cytogenetic mapping of the BCL9 gene to porcine chromosome 4". Anim. Genet. 33 (2): 162–3. doi:10.1046/j.1365-2052.2002.0831e.x. PMID 12047235.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447.
- Hoffmans R, Basler K (2004). "Identification and in vivo role of the Armadillo-Legless interaction". Development 131 (17): 4393–400. doi:10.1242/dev.01296. PMID 15294866.
- Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Sampietro J, Dahlberg CL, Cho US et al. (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". Mol. Cell 24 (2): 293–300. doi:10.1016/j.molcel.2006.09.001. PMID 17052462.
- Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272.
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