BCL2L14
| BCL2-like 14 (apoptosis facilitator) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | BCL2L14 ; BCLG | ||||||||||||
| External IDs | OMIM: 606126 MGI: 1914063 HomoloGene: 49840 GeneCards: BCL2L14 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 79370 | 66813 | |||||||||||
| Ensembl | ENSG00000121380 | ENSMUSG00000030200 | |||||||||||
| UniProt | Q9BZR8 | Q9CPT0 | |||||||||||
| RefSeq (mRNA) | NM_030766 | NM_025778 | |||||||||||
| RefSeq (protein) | NP_110393 | NP_080054 | |||||||||||
| Location (UCSC) | Chr 12: 12.2 – 12.36 Mb | Chr 6: 134.4 – 134.44 Mb | |||||||||||
| PubMed search | |||||||||||||
Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.[1][2]
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Four alternatively spliced transcript variants, which encode three distinct isoforms, have been reported for this gene.[2]
References
- ↑ Guo B, Godzik A, Reed JC (May 2001). "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family". J Biol Chem 276 (4): 2780–5. doi:10.1074/jbc.M005889200. PMID 11054413.
- ↑ 2.0 2.1 "Entrez Gene: BCL2L14 BCL2-like 14 (apoptosis facilitator)".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Montpetit A, Boily G, Sinnett D (2002). "A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus". European Journal of Human Genetics 10 (1): 62–71. doi:10.1038/sj.ejhg.5200766. PMID 11896457.
- Kutsenko AS, Gizatullin RZ, Al-Amin AN et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
- Ozalp SS, Yalcin OT, Tanir HM et al. (2003). "Bcl-2 expression in preinvasive and invasive cervical lesions". Eur. J. Gynaecol. Oncol. 23 (5): 419–22. PMID 12440815.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Montpetit A, Larose J, Boily G et al. (2004). "Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia". Leukemia 18 (9): 1499–504. doi:10.1038/sj.leu.2403441. PMID 15284860.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Soung YH, Lee JW, Park WS et al. (2006). "BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder". Pathology 38 (1): 33–4. doi:10.1080/00313020500455811. PMID 16484005.
- Lin ML, Park JH, Nishidate T et al. (2007). "Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family". Breast Cancer Res. 9 (1): R17. doi:10.1186/bcr1650. PMC 1851384. PMID 17280616.
- Yoo NJ, Soung YH, Lee SH et al. (2007). "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas". Tumori 93 (2): 195–7. PMID 17557568.