BCL2L10

BCL2-like 10 (apoptosis facilitator)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsBCL2L10 ; BCL-B; Boo; Diva
External IDsOMIM: 606910 MGI: 1330841 HomoloGene: 8396 ChEMBL: 5988 GeneCards: BCL2L10 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1001712049
EnsemblENSG00000137875ENSMUSG00000032191
UniProtQ9HD36Q9Z0F3
RefSeq (mRNA)NM_020396NM_013479
RefSeq (protein)NP_065129NP_038507
Location (UCSC)Chr 15:
52.4 – 52.4 Mb		Chr 9:
75.35 – 75.35 Mb
PubMed search

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.[1][2][3]

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.[3]

References

  1. ↑ Inohara N, Gourley TS, Carrio R, Muniz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Nunez G (Jan 1999). "Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death". J Biol Chem 273 (49): 32479–86. doi:10.1074/jbc.273.49.32479. PMID 9829980.
  2. ↑ Song Q, Kuang Y, Dixit VM, Vincenz C (Feb 1999). "Boo, a novel negative regulator of cell death, interacts with Apaf-1". EMBO J 18 (1): 167–78. doi:10.1093/emboj/18.1.167. PMC 1171112. PMID 9878060.
  3. ↑ 3.0 3.1 "Entrez Gene: BCL2L10 BCL2-like 10 (apoptosis facilitator)".

Further reading

  • van Oirschot JT (1999). "Diva vaccines that reduce virus transmission". J. Biotechnol. 73 (2–3): 195–205. doi:10.1016/S0168-1656(99)00121-2. PMID 10486928.
  • Pan G, O'Rourke K, Dixit VM (1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". J. Biol. Chem. 273 (10): 5841–5. doi:10.1074/jbc.273.10.5841. PMID 9488720.
  • Ke N, Godzik A, Reed JC (2001). "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak". J. Biol. Chem. 276 (16): 12481–4. doi:10.1074/jbc.C000871200. PMID 11278245.
  • Naumann U, Weit S, Wischhusen J, Weller M (2001). "Diva/Boo is a negative regulator of cell death in human glioma cells". FEBS Lett. 505 (1): 23–6. doi:10.1016/S0014-5793(01)02768-5. PMID 11557035.
  • Aouacheria A; Arnaud E; Venet S et al. (2001). "Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis". Oncogene 20 (41): 5846–55. doi:10.1038/sj.onc.1204740. PMID 11593390.
  • Zhang H, Holzgreve W, De Geyter C (2002). "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway". Hum. Mol. Genet. 10 (21): 2329–39. doi:10.1093/hmg/10.21.2329. PMID 11689480.
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Li Z, Takeuchi S, Ohara N, Maruo T (2003). "Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma". Int. J. Clin. Oncol. 8 (2): 83–9. doi:10.1007/s101470300015. PMID 12720100.
  • Kang Y; Lee DC; Han J et al. (2007). "NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling". Biochem. Biophys. Res. Commun. 359 (1): 76–82. doi:10.1016/j.bbrc.2007.05.090. PMID 17532299.
  • Guillemin Y; Lalle P; Gillet G et al. (2009). "Oocytes and early embryos selectively express the survival factor BCL2L10". J. Mol. Med. 87 (9): 923–40. doi:10.1007/s00109-009-0495-7. PMID 19551325.

External links