BCL10

B-cell CLL/lymphoma 10
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsBCL10 ; CARMEN; CIPER; CLAP; c-E10; mE10
External IDsOMIM: 603517 MGI: 1337994 HomoloGene: 2912 GeneCards: BCL10 Gene
Orthologs
SpeciesHumanMouse
Entrez891512042
EnsemblENSG00000142867ENSMUSG00000028191
UniProtO95999Q9Z0H7
RefSeq (mRNA)NM_003921NM_009740
RefSeq (protein)NP_003912NP_033870
Location (UCSC)Chr 1:
85.73 – 85.74 Mb		Chr 3:
145.92 – 145.93 Mb
PubMed search

B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.[1][2] Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma.

Function

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.[2]

Interactions

BCL10 has been shown to interact with:


References

  1. ↑ Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M et al. (March 1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell 96 (1): 35–45. doi:10.1016/S0092-8674(00)80957-5. PMID 9989495.
  2. ↑ 2.0 2.1 "Entrez Gene: BCL10 B-cell CLL/lymphoma 10".
  3. ↑ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA et al. (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
  4. ↑ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM et al. (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
  5. ↑ Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL et al. (Dec 2000). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–6. doi:10.1074/jbc.C000726200. PMID 11053425.
  6. ↑ Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J et al. (2012). "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes". J. Immunol. 188 (6): 2493–7. doi:10.4049/jimmunol.1101502. PMC 3294148. PMID 22323537.
  7. ↑ Wu CJ, Ashwell JD (February 2008). "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 105 (8): 3023–8. doi:10.1073/pnas.0712313105. PMC 2268578. PMID 18287044.
  8. ↑ Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV et al. (October 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell 6 (4): 961–7. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
  9. ↑ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T et al. (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917.

Further reading

  • Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. doi:10.1038/sj/thj/6200146. PMID 11960389.
  • Lee WC, Balsara B, Liu Z, Jhanwar SC, Testa JR (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma". Cancer Res. 56 (19): 4297–301. PMID 8813110.
  • Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger MO et al. (1999). "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10". J. Biol. Chem. 274 (15): 9955–9961. doi:10.1074/jbc.274.15.9955. PMID 10187770.
  • Thome M, Martinon F, Hofmann K, Rubio V, Steiner V, Schneider P et al. (1999). "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase". J. Biol. Chem. 274 (15): 9962–9968. doi:10.1074/jbc.274.15.9962. PMID 10187771.
  • Yan M, Lee J, Schilbach S, Goddard A, Dixit V (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic molecule". J. Biol. Chem. 274 (15): 10287–10292. doi:10.1074/jbc.274.15.10287. PMID 10187815.
  • Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L et al. (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)". Nat. Genet. 22 (1): 63–68. doi:10.1038/8767. PMID 10319863.
  • Srinivasula SM, Ahmad M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN et al. (1999). "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis". J. Biol. Chem. 274 (25): 17946–17954. doi:10.1074/jbc.274.25.17946. PMID 10364242.
  • Apostolou S, De Rienzo A, Murthy SS, Jhanwar SC, Testa JR (1999). "Absence of BCL10 mutations in human malignant mesothelioma". Cell 97 (6): 684–686. doi:10.1016/S0092-8674(02)09765-9. PMID 10380921.
  • Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–20132. doi:10.1074/jbc.274.29.20127. PMID 10400625.
  • Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T et al. (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–11120. doi:10.1074/jbc.275.15.11114. PMID 10753917.
  • Ye H, Dogan A, Karran L, Willis TG, Chen L, Wlodarska I et al. (2000). "BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma". Am. J. Pathol. 157 (4): 1147–1154. doi:10.1016/S0002-9440(10)64630-5. PMC 1850175. PMID 11021819.
  • Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL et al. (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–41086. doi:10.1074/jbc.C000726200. PMID 11053425.
  • Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV et al. (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell 6 (4): 961–967. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
  • Poyet JL, Srinivasula SM, Alnemri ES (2001). "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma". J. Biol. Chem. 276 (5): 3183–3187. doi:10.1074/jbc.C000792200. PMID 11113112.
  • Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S et al. (2001). "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure". Cell 104 (1): 33–42. doi:10.1016/S0092-8674(01)00189-1. PMID 11163238.
  • Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–21409. doi:10.1074/jbc.M102488200. PMID 11259443.
  • Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF et al. (2001). "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway". J. Biol. Chem. 276 (22): 19012–19019. doi:10.1074/jbc.M009984200. PMID 11262391.
  • Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–11882. doi:10.1074/jbc.M010512200. PMID 11278692.
  • Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–127. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.