BAALC
| brain and acute leukemia, cytoplasmic | |
|---|---|
| Identifiers | |
| Symbol | BAALC |
| Entrez | 79870 |
| HUGO | 14333 |
| OMIM | 606602 |
| RefSeq | NP_079088.1&rn=1 NP_001019543.1 NP_079088.1 |
| UniProt | Q8WXS3 |
| Other data | |
| Locus | Chr. 8 q22.3 |
BAALC (Brain and Acute Leukemia, Cytoplasmic)is a gene that has been associated with acute myeloid leukemia.[1] The gene is conserved among mammals and is not found in lower organisms.[2][3] Tissues that express this gene develop from the neuroectoderm.[2] Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines.[2] Among patients with acute myeloid leukemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukemia.[3] Some sources suggest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.[3]
References
- ↑ Tanner SM, Austin JL, Leone G et al. (November 2001). "BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13901–6. doi:10.1073/pnas.241525498. PMC 61139. PMID 11707601.
- ↑ 2.0 2.1 2.2 http://www.genecards.org/cgi-bin/carddisp.pl?gene=BAALC
- ↑ 3.0 3.1 3.2 http://www.pnas.org/content/98/24/13901.abstract
External links
- http://www.genecards.org/cgi-bin/carddisp.pl?gene=BAALC
- http://www.pnas.org/content/98/24/13901.abstract
- http://www.asco.org/portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confID=47&abstractID=33770 American Society of Clinical Oncology
- http://www.uniprot.org/uniprot/Q8WXS3