Axel T. Brunger

Axel T. Brunger (born November 25, 1956) is a German American biophysicist. He is Professor of Molecular and Cellular Physiology, and Neurology and Neurological Sciences at Stanford University, and a Howard Hughes Medical Institute Investigator.[1]

Early life

Brunger was born in Leipzig, Germany on November 25, 1956. He graduated with a degree in Physics and Mathematics from the University of Hamburg in 1977. He completed his Diplom in Physics from the University of Hamburg in 1980. He completed his PhD in Biophysics from Technical University of Munich in 1982, advised by Klaus Schulten.[2]

Academic career

Brunger held a NATO postdoctoral fellowship to work with Martin Karplus at Harvard University, where he subsequently became a research associate in the Department of Chemistry after a brief return to Germany.[2] He joined the Molecular Biophysics and Biochemistry department at Yale University in 1987 and moved to Stanford University in 2000.[1] Brunger was elected to the United States National Academy of Sciences in 2005[1] and won the inaugural DeLano Award for Computational Biosciences in 2011.[3]

Research

Brunger is known for developing a computer program called CNS used for solving structures based on X-ray diffraction or solution NMR data, which was first released in 1992. The program is a major extension of a 1987 program developed with John Kuriyan and Karplus called X-PLOR,[4] whose original inspiration was motivated by Marius Clore's efforts in interpreting NMR data and which has been extended by Clore's continued development of XPLOR-NIH.[2]

These programs make use of a method called simulated annealing in conjunction with molecular dynamics to refine protein structures. X-PLOR was the first time a modern optimization technique was applied to the problem of crystallographic refinement. Brunger also subsequently introduced the RFree technique to cross-validate the model given the observed data.[5] In the mid-1990s, his team extended X-PLOR into a complete system to solve structures, which then became the more full-featured tool CNS, capable of performing a series of steps necessary for crystallography structure determination, such as obtaining phases from experimental data and molecular replacement phasing from known homologous structures.[6]

Brunger's research group currently studies the molecular mechanism of synaptic vesicle fusion in neurotransmission.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 "Axel Brunger". Stanford School of Medicine. Retrieved 14 March 2015.
  2. ↑ 2.0 2.1 2.2 Mossman, K. (30 July 2008). "Profile of Axel Brunger". Proceedings of the National Academy of Sciences 105 (31): 10643–10645. doi:10.1073/pnas.0806286105.
  3. ↑ "Axel T. Brunger wins inaugural ASBMB DeLano Award". Retrieved 22 January 2015.
  4. ↑ Brünger, AT; Kuriyan, J; Karplus, M (23 January 1987). "Crystallographic R factor refinement by molecular dynamics.". Science (New York, N.Y.) 235 (4787): 458–60. PMID 17810339.
  5. ↑ Brunger AT (1992). "Free R value: a novel statistical quantity for assessing the accuracy of crystal structures". Nature (London) 355 (6359): 472–475. Bibcode:1992Natur.355..472B. doi:10.1038/355472a0. PMID 18481394.
  6. ↑ Brünger, AT; Adams, PD; Clore, GM; DeLano, WL; Gros, P; Grosse-Kunstleve, RW; Jiang, JS; Kuszewski, J; Nilges, M; Pannu, NS; Read, RJ; Rice, LM; Simonson, T; Warren, GL (1 September 1998). "Crystallography & NMR system: A new software suite for macromolecular structure determination.". Acta crystallographica. Section D, Biological crystallography 54 (Pt 5): 905–21. PMID 9757107.

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