Armin K.W. Kutzsche

Dr.med.
Armin K.W. Kutzsche
Born February 17, 1914[1]
Frankfurt am Main
Died February 19, 1995 (aged 81)
Frankfurt am Main
Resting place
 Frankfurt Main Cemetery
50°07′57″N 8°41′13″E / 50.1325000°N 008.6870000°E
Nationality German
Alma mater Goethe University Frankfurt
University of Freiburg
Occupation Physician and microbiologist
Employer Paul Ehrlich Institute
Goethe University Frankfurt
University of Freiburg
Cassella
Free University of Berlin
Schering AG
Merck
Signature

Armin Karl Wilhelm Kutzsche (born 17 February 1914 in Frankfurt am Main, died 19 February 1995 in Frankfurt am Main) was a German physician and medical researcher, whose research focused on medical microbiology, and antibacterial agents in particular. He was a researcher at the University of Freiburg, the Goethe University Frankfurt and the Free University of Berlin, and at the pharmaceutical companies Cassella, Schering, and Merck. He headed the bacteriological departments at Cassella and Schering in the 1950s and 1960s.

Career

He graduated as a physician at the Goethe University Frankfurt in 1937 and obtained a doctoral degree (Dr.med.) in 1939,[2] with a dissertation in the field of cancer research, on the influence on tumor grafts by lipoid tumors, based on research he had carried out at the Senckenberg Institute of Pathology from 1936. His doctoral supervisor was Bernhard Fischer-Wasels.[3][4] He later became a specialist in internal medicine.[1][2] He was awarded the golden doctorate at the Goethe University in 1989.

He was a medical intern at the State Institute for Experimental Therapy (now the Paul Ehrlich Institute) and the Kurhospital (spa hospital) in Bad Nauheim 1937–1938 and worked at the Frankfurt University Neuropsychiatric Clinic (headed by Karl Kleist) 1938–1939. After serving as a conscripted military physician (captain) in the Army Medical Service,[5] he worked as a bacteriologist at the Institute of Medical Microbiology and Hygiene at the University of Freiburg from 1943 and at Paul Uhlenhuth's State Research Laboratory in Freiburg from 1944. Between 1945 and 1949, he was an assistant physician and from 1946 assistant professor at the Institute for Medical Microbiology and Infection Control at the Goethe University Frankfurt, led by the immunologist Hans Schlossberger, working in the field of bacteriology and infectious diseases.[1]

From 1949 to 1959 he was director of the Chemotherapeutic-Bacteriological Laboratory at the chemical and pharmaceutical company Cassella (now Sanofi) in Frankfurt.[2] He then relocated to West Berlin to become director of the Department of Bacteriology at Schering AG (now Bayer HealthCare Pharmaceuticals) 1959–1965. He was also affiliated with the Research Department of Electron Microscopy at the Free University of Berlin. From 1965 to 1968 he was a researcher at the Chemotherapeutic Laboratory of Merck in Darmstadt. He left Merck and became chief physician at the geriatric clinic in Düsseldorf-Flehe 1968–1970. He was a general practitioner and chirotherapist in Offenbach am Main during the years 1970–1984, until he relocated to Frankfurt upon his retirement.[1]

Research and scholarship

His scholarly work focused on bacteriology, including antibacterial agents. He has published papers in Medical Microbiology and Immunology, Immunobiology, Drug Research, Cell and Tissue Research, Chemotherapy, Microbiological Research, Antibiotics and Chemotherapy, Naturwissenschaften, the Journal of Molecular Medicine, and other journals.

He was a co-inventor of several patents held by German pharmaceutical companies, in collaboration with Adolf Stachel, Werner Zerweck, Mahmoud K. Muftić and others. In the early 1950s, he developed Nu-nu-dibenzylsulfamyl benzoic acid, US patent US2805250 A, with Stachel and Zerweck.[6] He developed 3-methyl-5-isopropylphenyl esters of n-pyrrolidino and n-morpholino carboxylic acids, US patent US3457262 A, for use as dermatological fungicides and as tranquilizers, with Mahmoud K. Muftić and Horst Peissker,[7] and bacteria-inhibiting steroids, US patent US3415817 A, with Emanuel Kaspar, Gerhard Hempel and Rainer Philippson.[8] He also collaborated with Willy Schwarz and Hans-Joachim Merker at the Free University of Berlin in research on fibroblasts.

He was also a contributor to the final edition (1952) of Kolle and Hetsch's book Experimental Bacteriology, one of the most authoritative works in microbiology in its time. He was a member of the editorial boards of the academic journals Internal Medicine (from 1948), Microbiological Research (from 1949) and Physiology, Physiological Chemistry, Pharmacology (from 1956). He was a member of the German Society for Hygiene and Microbiology, of the Senckenberg Nature Research Society and of the Schopenhauer Society.[1][9]

Background

He was a son of an auditor and head of the Frankfurt Oberjustizkasse, and married the pediatrician (Dr.med.) Erika Berdel (1919–1951), daughter of Frankfurt chief veterinarian (Dr.med.vet.) Gustav Berdel and Hermine Bovensiepen, in 1943. He married Louise Paus Haagaas (1917–2009), from Oslo and daughter of the Norwegian mathematician Theodor Haagaas and Henriette Wegner Paus, in 1953.

Selected scientific publications

  • Kutzsche A (1938). Über die Beeinflussung von Transplantattumoren durch Tumorlipoide [On the influence on tumor grafts by lipoid tumors]. Gelnhausen, F. W. Kalbfleisch. Medical dissertation, 3 March 1939 (Diss. 1939/2626 Univ. Frankfurt).
  • Contributor to Kolle W, Hetsch H, Schlossberger H (eds.) (1952), Experimentelle Bakteriologie und Infektionskrankheiten (= Experimental Bacteriology), Munich, Urban & Schwarzenberg
Scientific papers
  • Kutzsche A (1949). Beeinflussung von Transplantattumoren durch Tumorlipoide [Influence on tumor grafts by lipoid tumors]. Zeitschrift für Hygiene und Infectionskrankheiten (= Medical Microbiology and Immunology), Vol. 129, No. 3–4, pp. 278–287 (partly based on the above dissertation).
  • Kutzsche A (1949). Ätiologie und Immunotherapie der Experimentaltumoren [Aetiology and immunotherapy of experimental tumors]. Med.Monatsschrift 3, 493–98.
  • Kutzsche, A (1950). Epidemiologische Studien über Morbus Weil [Epidemiological studies of Weil's Disease]. Zeitschrift für Immunitätsforschung (= Immunobiology) 107, 257–266.
  • Knott T, Walter AM, Kutzsche A (1961). Antibakterielle Wirksamkeit des 2-Sulfanilamido-5-methoxy-pyrimidins [Antibacterial effectiveness of 2-sulfanilamido-5-methoxy-pyrimidine]. Arzneimittelforschung (= Drug Research) 11:684–694.
  • Schwarz W, Merker HJ, Kutzsche A (1962). Elektronenmikroskopische Untersuchungen über die Fibrillogenese in Fibroblastenkulturen [Electron microscopic studies on fibrillogenesis in fibroblast cultures]. Zeitschrift für Zellforschung und Mikroskopische Anatomie (= Cell and Tissue Research) Vol. 56, No. 1, pp. 107–124 .
  • Kutzsche A (1962). Die minimale Hemmkonzentration von Sulfanilamiden. Das Ärztliche Laboratorium: Zeitschrift für den Laboratoriumsarzt und die ärztliche Praxis, 8:330–332.
  • Knott T, Walter AM, Kutzsche A (1962). Die Bestimmung der in-vitro-Empfindlichkeit von Bakterien gegen Durenat. Med. Mitt. (Schering) 14.
  • Schwarz W, Merker HJ, Kutzsche A (1964). Elektronenmikroskopische Untersuchungen an verfetteten Fibroblastenkulturen nach verzögerter Umsetzung [Electron microscopic studies on fibroblast cultures having undergone fatty degeneration after retarded double decomposition]. Zeitschrift fur Zellforschung und Mikroskopische Anatomie (= Cell and Tissue Research) 64:804-812.
  • Kutzsche A (1964). Einige mikrobiologische Besonderheiten neuerer Sulfanilamide [Some microbiological characteristics of newer Sulfanilamides]. Chemotherapia (= Chemotherapy) 1964;8:53–62. doi: 10.1159/000220295.
  • Kutzsche A (1964). Die Färbung der Tuberkelbakterien [Staining of tubercle bacteria]. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (= Microbiological Research) 194(2):252-4.
  • Kutzsche A (1964). Die Bedeutung der in vitro-Teste für die klinische Prüfung von Chemotherapeutica [The importance of in vitro tests for the clinical testing of chemotherapeutic agents]. Antibiot. Chemother. Fortschr. (Basel) (= Antibiotics and Chemotherapy) 12: 315–333.
  • Kutzsche A (1964). Vorkommen und Verteilung der Tuberkelbakterien während des Ablaufes der Lungentuberkulose und ihr färberischer Nachweis mit Viktoriablau 4 R [Occurrence and distribution of tubercle bacilli during the course of pulmonary tuberculosis and its demonstration by staining with Victoria blue 4 R]. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (= Microbiological Research) 1964 Jul; 193(2):196–9.
  • Kutzsche A (1964). The Minimum Inhibitory Concentration of Sulfanilamides. Progress in Immunobiological Standardization 1: 48–51.
  • Kutzsche A (1965). Zur Toxikologie des Dimethylformamids [On the toxicology of dimethylformamide]. Arzneimittelforschung (= Drug Research) 15(6):618-624.
  • Kutzsche A (1965). Beitrag zur Diagnostik der Tuberkelbakterien [On the diagnosis of tubercle bacteria]. Das Ärztliche Laboratorium: Zeitschrift für den Laboratoriumsarzt und die ärztliche Praxis 11: 4–10.
  • Kutzsche A, Merker HJ, Schwarz W (1965). Morphologische Beobachtungen über die Sulfanilamideinwirkung auf Fibroblastenkulturen [Morphological observations on the influence of sulfanilamide on fibroblast cultures]. Naturwissenschaften, vol. 52, no. 5, pp. 118–118. doi: 10.1007/BF00626341.
  • Gerhards E, Gibian H, Kutzsche, A (1965). Sulfonamidausscheidung und bacteriostatische Aktivität im Harn nach oraler Verabreichung des Langzeitsulfonamids 2-Sulfanilamido-5-methoxypyrimidin (Sulfamethoxydiazin) und des Kurzzeitsulfonamids N-Sulfanilylcarbamid [Sulfonamide excretion and bacteriostatic activity in urine after oral administration of the long-term sulfonamide 2-sulfanilamido-5-methoxy-pyrimidine (sulfamethoxydiazine) and the short-term sulfonamide N-sulfanilylcarbamide]. Arzneimittelforschung (= Drug Research) 15: 512–516.
  • Schwarz W, Kutzsche A (1966). Elektronenmikroskopische Untersuchungen über die anabole und katabole Wirkung von Dexamethason und Methenolonester auf Fibroblasten in vitro [Electron microscopic studies on the anabolic and catabolic effects of dexamethasone and methenolonester on fibroblasts in vitro]. Klinische Wochenschrift (= Journal of Molecular Medicine), Volume 44, Issue 16, pp. 979–982. doi: 10.1007/BF01711473.
  • Kutzsche A, Vöge HO (1966). Zur Verträglichkeit einer Gentamycin-Creme [The compatibility of Gentamicin cream]. Arzneimittelforschung (= Drug Research) 16(1):11-14.
Patents

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Lüdtke, Gerhard; Strodel, Hans; Jaeger, Hans, eds. (1961). "Kutzsche, Armin". Kürschners Deutscher Gelehrten-Kalender 1 (9 ed.). Walter de Gruyter. p. 1132.
  2. ↑ 2.0 2.1 2.2 Lüdtke, Gerhard; Strodel, Hans; Jaeger, Hans, eds. (1954). "Kutzsche, Armin". Kürschners Deutscher Gelehrten-Kalender (8 ed.). Walter de Gruyter. p. 684.
  3. ↑ Über die Beeinflussung von Transplantattumoren durch Tumorlipoide, stabikat.de
  4. ↑ "Armin Karl Wilhelm Kutzsche". PhDTree: Academic Genealogy. Retrieved 2015-04-08.
  5. ↑ "Kutzsche, Armin Karl Wilhelm." Military record, Deutsche Dienststelle (WASt)
  6. ↑ Nu-nu-dibenzylsulfamyl benzoic acid: US 2805250 A
  7. ↑ 3-methyl-5-isopropylphenyl esters of n-pyrrolidino and n-morpholino carboxylic acids: US 3457262 A
  8. ↑ Bacteria-inhibiting steroids and method of making the same: US 3415817 A
  9. ↑ Schopenhauer-Jahrbuch, 1987, p. 297, Verlag Valdemar Kramer

External links