Aprindine
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| Systematic (IUPAC) name | |
|---|---|
| {3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Identifiers | |
37640-71-4  | |
| C01BB04 | |
| PubChem | CID 2218 |
| DrugBank |
DB01429 |
| ChemSpider |
2132 |
| UNII |
5Y48085P9Q |
| KEGG |
D02969 |
| ChEMBL |
CHEMBL1213033 |
| Chemical data | |
| Formula | C22H30N2 |
| 322.487 g/mol | |
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SMILES
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Aprindine is a Class 1b antiarrhythmic agent.[1]
In one study, it delayed atrial fibrillation more than digoxin did.[2]
It has shown effectiveness when given orally.[3]
References
- ↑ Sato R, Hisatome I, Tanaka Y et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
- ↑ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation" ([DEAD LINK]). Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.
- ↑ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.
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