Apolipoprotein C4
| Apolipoprotein C-IV | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | APOC4 ; APO-CIV; APOC-IV | ||||||||||||
| External IDs | OMIM: 600745 MGI: 87878 HomoloGene: 1245 GeneCards: APOC4 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 346 | 11425 | |||||||||||
| Ensembl | ENSG00000224916 | ENSMUSG00000074336 | |||||||||||
| UniProt | P55056 | Q61268 | |||||||||||
| RefSeq (mRNA) | NM_001646 | NM_007385 | |||||||||||
| RefSeq (protein) | NP_001637 | NP_031411 | |||||||||||
| Location (UCSC) | Chr 19: 45.45 – 45.45 Mb | Chr 7: 19.68 – 19.68 Mb | |||||||||||
| PubMed search | |||||||||||||
Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.[1][2]
Function
Apolipoprotein (apo)C4 gene is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. Apo C4 is a 3.3-kb gene consisting of 3 exons and 2 introns; it is located 0.5 kb 5' to the APOC2 gene.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: apolipoprotein C-IV".
- ↑ Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus". Genomics 28 (2): 291–300. doi:10.1006/geno.1995.1144. PMID 8530039.
Further reading
- Kim E, Li K, Lieu C et al. (2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis.". J. Hepatol. 49 (5): 787–98. doi:10.1016/j.jhep.2008.06.029. PMC 2644636. PMID 18809223.
- Burkhardt R, Kenny EE, Lowe JK et al. (2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13". Arterioscler. Thromb. Vasc. Biol. 28 (11): 2078–84. doi:10.1161/ATVBAHA.108.172288. PMC 2764366. PMID 18802019.
- Willer CJ, Sanna S, Jackson AU et al. (2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161–9. doi:10.1038/ng.76. PMID 18193043.
- Mak PA, Laffitte BA, Desrumaux C et al. (2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta". J. Biol. Chem. 277 (35): 31900–8. doi:10.1074/jbc.M202993200. PMID 12032151.
- Liu T, Qian WJ, Gritsenko MA et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Kathiresan S, Willer CJ, Peloso GM et al. (2009). "Common variants at 30 loci contribute to polygenic dyslipidemia". Nat. Genet. 41 (1): 56–65. doi:10.1038/ng.291. PMC 2881676. PMID 19060906.
- Mosbruger TL, Duggal P, Goedert JJ et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC 2853721. PMID 20331378.
- Ken-Dror G, Talmud PJ, Humphries SE, Drenos F (2010). "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular medicine (Cambridge, Mass.) 16 (9–10): 389–99. doi:10.2119/molmed.2010.00044. PMC 2935949. PMID 20498921.
- Marques-Vidal P, Bochud M, Paccaud F et al. (2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels". Atherosclerosis 211 (2): 551–7. doi:10.1016/j.atherosclerosis.2010.04.001. PMID 20430392.
- Talmud PJ, Drenos F, Shah S et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
- Drenos F, Talmud PJ, Casas JP et al. (2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 (12): 2305–16. doi:10.1093/hmg/ddp159. PMC 2685759. PMID 19336475.
- Kathiresan S, Melander O, Guiducci C et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
- Mancone C, Amicone L, Fimia GM et al. (2007). "Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF". Proteomics 7 (1): 143–54. doi:10.1002/pmic.200600339. PMID 17154273.
- Lowe JK, Maller JB, Pe'er I et al. (2009). Gibson, Greg, ed. "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae". PLoS Genet. 5 (2): e1000365. doi:10.1371/journal.pgen.1000365. PMC 2628735. PMID 19197348.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kamboh MI, Aston CE, Hamman RF (2000). "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile". Atherosclerosis 152 (1): 193–201. doi:10.1016/S0021-9150(99)00459-1. PMID 10996355.
- Klos KL, Sing CF, Boerwinkle E et al. (2006). "Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants". Arterioscler. Thromb. Vasc. Biol. 26 (8): 1828–36. doi:10.1161/01.ATV.0000231523.19199.45. PMID 16763159.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kotite L, Zhang LH, Yu Z et al. (2003). "Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins". J. Lipid Res. 44 (7): 1387–94. doi:10.1194/jlr.M300087-JLR200. PMID 12700345.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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