Aphthovirus internal ribosome entry site (IRES)
| Aphthovirus internal ribosome entry site (IRES) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of IRES_Aptho | |
| Identifiers | |
| Symbol | IRES_Aptho |
| Alt. Symbols | Aptho_IRES |
| Rfam | RF00210 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | 0043022 |
| SO | 0000243 |
This family represents the internal ribosome entry site (IRES) of the Picornaviruses.[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F.[2]
References
- ↑ Fernandez-Miragall, O; Martinez-Salas E (2003). "Structural organization of a viral IRES depends on the integrity of the GNRA motif". RNA 9 (11): 1333–1344. doi:10.1261/rna.5950603. PMC 1287055. PMID 14561883.
- ↑ Kolupaeva, VG; Pestova TV; Hellen CU (2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049. PMID 11142379.