Antiestrogen
An antiestrogen is a substance that blocks the production or utilization of estrogens,[1] or inhibits their effects.[2] (Estrogens are the family of hormones that promote the development and maintenance of female sex characteristics.)
Antiestrogens like tamoxifen can promote an invasive phenotype in estrogen receptor (ER)-positive breast cancer cells with deficient intercellular adhesion.
Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class.[3] Aromatase inhibitors reduce the production of estrogen, while the term "antiestrogen" is usually reserved for agents reducing the response to estrogen.[4]
See also
- Estrogen
- SERM
- Aromatase inhibitor
- Antiandrogen
- Antiprogestin
- Anti-oestrogenic diet
References
- ↑ "Definition of antiestrogen - NCI Dictionary of Cancer Terms, Definition of antiestrogen - NCI Dictionary of Cancer Terms".,
- ↑ "antiestrogen" at Dorland's Medical Dictionary
- ↑ Riggins RB, Bouton AH, Liu MC, Clarke R (2005). "Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer". Vitam. Horm. 71: 201–37. doi:10.1016/S0083-6729(05)71007-4. PMID 16112269.
- ↑ Thiantanawat, Long, Brodie, Apinya, Brian, Angela (2003-11-15). "Signaling Pathways of Apoptosis Activated by Aromatase Inhibitors and Antiestrogens". The Journal of Cancer Research. Retrieved 2015-04-13.
External links
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
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