Anistreplase

Anistreplase
Clinical data
Trade names Eminase
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pharmacokinetic data
Half-life 90 minutes
Identifiers
81669-57-0 Yes
B01AD03
DrugBank DB00029 Yes
KEGG D02947 Yes
Chemical data
approx. 131,000 g/mol
 Yes (what is this?)  (verify)

Anistreplase is a thrombolytic drug.[1][2][3]

Anistreplase has been developed by Beecham as Eminase. It is also known as anisoylated plasminogen streptokinase activator complex (APSAC)

Mechanism

It is a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme's active site. When the drug is administered, the acyl group gets hydrolyzed, thereby freeing the activator complex. It converts plasminogen to plasmin, which in turn degrades fibrin (blood clots) to fibrin split products.

References

  1. ↑ Rawles J (January 1996). "Magnitude of benefit from earlier thrombolytic treatment in acute myocardial infarction: new evidence from Grampian region early anistreplase trial (GREAT)". BMJ 312 (7025): 212–5. doi:10.1136/bmj.312.7025.212. PMC 2350007. PMID 8563585.
  2. ↑ Hannaford P, Vincent R, Ferry S, Hirsch S, Kay C (April 1995). "Assessment of the practicality and safety of thrombolysis with anistreplase given by general practitioners". Br J Gen Pract 45 (393): 175–9. PMC 1239197. PMID 7612317.
  3. ↑ Rawles J, Light J (October 1993). "Loss of quality adjusted days as a trial endpoint: effect of early thrombolytic treatment in suspected myocardial infarction. Grampion Region Early Anistreplase Trial (GREAT)". J Epidemiol Community Health 47 (5): 377–381. doi:10.1136/jech.47.5.377. PMC 1059832. PMID 8289038.